ENSDARG00000101831


Danio rerio

Features
Gene ID: ENSDARG00000101831
  
Biological name :irx1a
  
Synonyms : iroquois homeobox 1a / irx1a
  
Possible biological names infered from orthology : Iroquois-class homeodomain protein IRX-1 / iroquois homeobox 1 / IRX1 / P78414 / P81068
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 813780
Gene end: 817937
  
Corresponding Affymetrix probe sets: Dr.12613.1.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000137032
Ensembl peptide - ENSDARP00000137879
swissprot - A0A0R4ILR3
swissprot - B3DKL9
ZFIN ID - ZDB-GENE-040707-1
Ensembl - ENSDARG00000101831
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRX1ENSGALG00000030991Gallus gallus
 IRX1ENSG00000170549Homo sapiens
 Irx1ENSMUSG00000060969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irx1b / iroquois homeobox 1bENSDARG0000005659451
irx3a / iroquois homeobox 3a / IRX3* / P78415* / P81067* / iroquois homeobox 3* / Iroquois-class homeodomain protein IRX-3 *ENSDARG0000010107642
irx3b / iroquois homeobox 3b / IRX3* / P78415* / iroquois homeobox 3*ENSDARG0000003113834
irx5a / iroquois homeobox 5a / IRX5* / P78411* / Q9JKQ4* / iroquois homeobox 5* / Iroquois-class homeodomain protein IRX-5 *ENSDARG0000003404332
irx6a / iroquois homeobox 6a / IRX6* / P78412* / Q9ER75* / iroquois homeobox 6* / Iroquois-class homeodomain protein IRX-6 *ENSDARG0000003442031
irx4a / iroquois homeobox 4a / IRX4* / P78413* / Q9QY61* / iroquois homeobox 4* / Iroquois-class homeodomain protein IRX-4 *ENSDARG0000003564830
irx2a / iroquois homeobox 2a / IRX2* / P81066* / Q9BZI1* / iroquois homeobox 2* / Iroquois-class homeodomain protein IRX-2 *ENSDARG0000000178529
irx4b / iroquois homeobox 4b / IRX4* / P78413* / Q9QY61* / iroquois homeobox 4* / Iroquois-class homeodomain protein IRX-4 *ENSDARG0000003605128
irx5b / iroquois homeobox 5b / IRX5* / P78411* / Q9JKQ4* / iroquois homeobox 5* / Iroquois-class homeodomain protein IRX-5 *ENSDARG0000007407027
irx7 / iroquois homeobox 7ENSDARG0000000260126
mkxa / mohawk homeobox a / MKX* / Q8IYA7* / mohawk homeobox*ENSDARG0000007545017
mkxb / mohawk homeobox b / MKX* / Q8IYA7* / mohawk homeobox*ENSDARG0000011418215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IDA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0021953 central nervous system neuron differentiation IMP
 biological_processGO:0031076 embryonic camera-type eye development IMP
 biological_processGO:0035118 embryonic pectoral fin morphogenesis IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer hypoplastic , abnormal
Show

 ZFA:0000029 hindbrain hindbrain antero-ventral region apoptotic , abnormal
hindbrain serotonergic neuron decreased amount , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer morphology , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart decreased contractility , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer malformed , abnormal
retinal inner nuclear layer neuron decreased amount , abnormal
retinal inner nuclear layer hypoplastic , abnormal
Show

 ZFA:0000152 retina retina malformed , abnormal
retina undifferentiated , abnormal
retina neuron decreased amount , abnormal
retina morphology , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal aplastic , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism increased pigmentation , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased length , abnormal
pectoral fin stubby , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer malformed , abnormal
Show

 ZFA:0009091 melanocyte melanocyte melanosome increased distribution , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell decreased amount , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell decreased amount , abnormal
Show

 ZFA:0009280 Muller cell Muller cell absent , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell decreased amount , abnormal
Show

 ZFA:0009318 retinal bipolar neuron retinal bipolar neuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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