ENSG00000184363


Homo sapiens

Features
Gene ID: ENSG00000184363
  
Biological name :PKP3
  
Synonyms : PKP3 / plakophilin 3 / Q9Y446
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.5
Gene start: 392614
Gene end: 404908
  
Corresponding Affymetrix probe sets: 209872_s_at (Human Genome U133 Plus 2.0 Array)   209873_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000331678
Ensembl peptide - ENSP00000436847
Ensembl peptide - ENSP00000435522
Ensembl peptide - ENSP00000435478
Ensembl peptide - ENSP00000435383
Ensembl peptide - ENSP00000434517
Ensembl peptide - ENSP00000434110
NCBI entrez gene - 11187     See in Manteia.
OMIM - 605561
RefSeq - NM_001303029
RefSeq - NM_007183
RefSeq Peptide - NP_001289958
RefSeq Peptide - NP_009114
swissprot - H0YEY5
swissprot - E9PRW6
swissprot - Q9Y446
swissprot - E9PQ15
swissprot - E9PKC4
swissprot - E9PK71
swissprot - E9PJR7
Ensembl - ENSG00000184363
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkp3aENSDARG00000051861Danio rerio
 pkp3bENSDARG00000079438Danio rerio
 PKP3ENSGALG00000004260Gallus gallus
 Pkp3ENSMUSG00000054065Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PKP2 / Q99959 / plakophilin 2ENSG0000005729428
PKP1 / Q13835 / plakophilin 1ENSG0000008127727
CTNND2 / Q9UQB3 / catenin delta 2ENSG0000016986226
PKP4 / Q99569 / plakophilin 4ENSG0000014428325
ARVCF / O00192 / ARVCF, delta catenin family memberENSG0000009988925
CTNND1 / O60716 / catenin delta 1ENSG0000019856123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR028434  Plakophilin-3
 IPR028435  Plakophilin/Delta catenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002159 desmosome assembly IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0031424 keratinization TAS
 biological_processGO:0070268 cornification TAS
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1902373 negative regulation of mRNA catabolic process IMP
 cellular_componentGO:0001533 cornified envelope TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction TAS
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IEA
 cellular_componentGO:1990124 messenger ribonucleoprotein complex IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0045294 alpha-catenin binding IPI
 molecular_functionGO:0050839 cell adhesion molecule binding IPI
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IDA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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