ENSG00000188786


Homo sapiens

Features
Gene ID: ENSG00000188786
  
Biological name :MTF1
  
Synonyms : metal regulatory transcription factor 1 / MTF1 / Q14872
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.3
Gene start: 37809567
Gene end: 37859620
  
Corresponding Affymetrix probe sets: 205322_s_at (Human Genome U133 Plus 2.0 Array)   205323_s_at (Human Genome U133 Plus 2.0 Array)   227150_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362127
NCBI entrez gene - 4520     See in Manteia.
OMIM - 600172
RefSeq - XM_011541494
RefSeq - NM_005955
RefSeq - XM_011541491
RefSeq - XM_011541493
RefSeq Peptide - NP_005946
swissprot - Q14872
Ensembl - ENSG00000188786
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtf1ENSDARG00000102898Danio rerio
 MTF1ENSGALG00000001639Gallus gallus
 Mtf1ENSMUSG00000028890Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ZXDC / Q2QGD7 / ZXD family zinc finger CENSG0000007047622
P52747 / ZNF143 / zinc finger protein 143ENSG0000016647819
ZXDB / P98169 / zinc finger, X-linked, duplicated BENSG0000019845519
ZXDA / P98168 / zinc finger, X-linked, duplicated AENSG0000019820519
ZNF76 / P36508 / zinc finger protein 76ENSG0000006502919
Q86VK4 / ZNF410 / zinc finger protein 410ENSG0000011972515
GTF3A / Q92664 / general transcription factor IIIAENSG0000012203410
YY1 / P25490 / YY1 transcription factorENSG000001008119
YY2 / O15391 / YY2 transcription factorENSG000002307978
ZFP42 / Q96MM3 / ZFP42 zinc finger proteinENSG000001790598


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR029796  Metal regulatory transcription factor 1
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0010038 response to metal ion TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046686 response to cadmium ion IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
MTF1 activates gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188786 MTF1 / Q14872 / metal regulatory transcription factor 1  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr