ENSGALG00000017200


Gallus gallus

Features
Gene ID: ENSGALG00000017200
  
Biological name :MTMR2
  
Synonyms : MTMR2 / Myotubularin-related protein 2 / Q5ZIV1
  
Possible biological names infered from orthology : Q13614 / Q9Z2D1
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 185245430
Gene end: 185284458
  
Corresponding Affymetrix probe sets: Gga.2647.1.S1_at (Chicken Array)   GgaAffx.12786.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027747
Ensembl peptide - ENSGALP00000042583
NCBI entrez gene - 418992     See in Manteia.
RefSeq - XM_015279973
RefSeq - NM_001039274
RefSeq - XM_015279951
RefSeq - XM_015279958
RefSeq - XM_015279966
RefSeq Peptide - NP_001034363
swissprot - Q5ZIV1
swissprot - R4GK94
Ensembl - ENSGALG00000017200
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtmr2ENSDARG00000004616Danio rerio
 MTMR2ENSG00000087053Homo sapiens
 Mtmr2ENSMUSG00000031918Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTMR1 / myotubularin related protein 1 / Q13613* / Q9Z2C4*ENSGALG0000000908574
MTM1 / myotubularin 1 / Q13496* / Q9Z2C5* / X-linked myotubular myopathy gene 1*ENSGALG0000000909639
MTMR6 / myotubularin related protein 6 / Q8VE11* / Q9Y217*ENSGALG0000001711237
MTMR3 / myotubularin related protein 3 / Q13615*ENSGALG0000000805137
MTMR8 / myotubularin-related protein 8 / Q96EF0*ENSGALG0000000759037
MTMR4 / myotubularin related protein 4 / Q91XS1* / Q9NYA4* / Mus musculus myotubularin related protein 4 (Mtmr4), transcript variant 2, mRNA.*ENSGALG0000000104236
MTMR9 / myotubularin-related protein 9 / Q96QG7* / Q9Z2D0*ENSGALG0000001664932
SBF1 / SET binding factor 1 / O95248* / Q6ZPE2*ENSGALG0000004317830
SBF2 / SET binding factor 2 / Q86WG5*ENSGALG0000000571630
ENSGALG0000000331328
MTMR7* / Q9Y216* / Q9Z2C9* / myotubularin related protein 7*ENSGALG0000001364118
MTMR7* / Q9Y216* / Q9Z2C9* / myotubularin related protein 7*ENSGALG0000003602110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR004182  GRAM domain
 IPR010569  Myotubularin-like phosphatase domain
 IPR011993  PH-like domain superfamily
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030564  Myotubularin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0031642 negative regulation of myelination IEA
 biological_processGO:0032288 myelin assembly IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0060304 regulation of phosphatidylinositol dephosphorylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005774 vacuolar membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity ISS
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA
 molecular_functionGO:0052866 phosphatidylinositol phosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the ER membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003168 MTMR12 / myotubularin related protein 12 / Q80TA6* / Q9C0I1* / Mus musculus myotubularin related protein 12 (Mtmr12), transcript variant 2, mRNA.*  / reaction / complex
 ENSGALG00000043178 SBF1 / SET binding factor 1 / O95248* / Q6ZPE2*  / complex / reaction






 

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