ENSMUSG00000000605


Mus musculus

Features
Gene ID: ENSMUSG00000000605
  
Biological name :Clcn4
  
Synonyms : Clcn4 / Mus musculus chloride channel, voltage-sensitive 4 (Clcn4), transcript variant 7, mRNA. / Q61418
  
Possible biological names infered from orthology : chloride voltage-gated channel 4 / P51793
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 7282309
Gene end: 7300851
  
Corresponding Affymetrix probe sets: 10559853 (MoGene1.0st)   1415986_at (Mouse Genome 430 2.0 Array)   1448161_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147562
Ensembl peptide - ENSMUSP00000147449
Ensembl peptide - ENSMUSP00000147627
Ensembl peptide - ENSMUSP00000148174
Ensembl peptide - ENSMUSP00000148061
Ensembl peptide - ENSMUSP00000000619
NCBI entrez gene - 12727     See in Manteia.
MGI - MGI:104571
RefSeq - XM_017321961
RefSeq - NM_001302386
RefSeq - NM_001302387
RefSeq - NM_001357103
RefSeq - NM_011334
RefSeq - XM_006539501
RefSeq - XM_006539502
RefSeq - XM_006539503
RefSeq - XM_006539504
RefSeq - XM_006539507
RefSeq - XM_011250426
RefSeq Peptide - NP_001344032
RefSeq Peptide - NP_035464
RefSeq Peptide - NP_001289315
RefSeq Peptide - NP_001289316
RefSeq Peptide - NP_001344031
swissprot - Q3LRV6
swissprot - Q61418
swissprot - A0A1B0GT29
swissprot - A0A1B0GST3
swissprot - A0A1B0GRR0
swissprot - A0A1B0GRB0
Ensembl - ENSMUSG00000000605
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clcn4ENSDARG00000035808Danio rerio
 CLCN4ENSGALG00000016607Gallus gallus
 CLCN4ENSG00000073464Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clcn5 / Q9WVD4 / H(+)/Cl(-) exchange transporter 5 / P51795* / chloride voltage-gated channel 5*ENSMUSG0000000431777
Clcn3 / P51791 / H(+)/Cl(-) exchange transporter 3 / P51790* / chloride voltage-gated channel 3*ENSMUSG0000000431976
Clcn7 / O70496 / H(+)/Cl(-) exchange transporter 7 / P51798* / chloride voltage-gated channel 7*ENSMUSG0000003663629
Clcn6 / O35454 / Chloride transport protein 6 / P51797* / chloride voltage-gated channel 6*ENSMUSG0000002901628
Clcn2 / Q9R0A1 / Chloride channel protein 2 / P51788* / chloride voltage-gated channel 2*ENSMUSG0000002284324
Clcn1 / Q64347 / Chloride channel protein 1 / P35523* / chloride voltage-gated channel 1*ENSMUSG0000002986223
Clcnka / Q9WUB7 / Chloride channel protein ClC-Ka / CLCNKB* / P51800* / P51801* / chloride voltage-gated channel Kb* / chloride voltage-gated channel Ka*ENSMUSG0000003377021
Q9WUB6 / Clcnkb / Chloride channel protein ClC-Kb / CLCNKA* / P51800* / P51801* / chloride voltage-gated channel Ka* / chloride voltage-gated channel Kb*ENSMUSG0000000621620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001807  Chloride channel, voltage gated
 IPR002246  Chloride channel ClC-4
 IPR014743  Chloride channel, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005247 voltage-gated chloride channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015297 antiporter activity ISO


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011445 abnormal renal protein reabsorption "any anomaly in the process in which proteins are taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0097017]
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Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr