ENSMUSG00000029016


Mus musculus

Features
Gene ID: ENSMUSG00000029016
  
Biological name :Clcn6
  
Synonyms : Chloride transport protein 6 / Clcn6 / O35454
  
Possible biological names infered from orthology : chloride voltage-gated channel 6 / P51797
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 148004259
Gene end: 148038821
  
Corresponding Affymetrix probe sets: 10518428 (MoGene1.0st)   1422314_at (Mouse Genome 430 2.0 Array)   1455440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030879
Ensembl peptide - ENSMUSP00000121751
Ensembl peptide - ENSMUSP00000116153
Ensembl peptide - ENSMUSP00000101336
NCBI entrez gene - 26372     See in Manteia.
MGI - MGI:1347049
RefSeq - XM_006538876
RefSeq - NM_011929
RefSeq Peptide - NP_036059
swissprot - D6RHT0
swissprot - E9Q741
swissprot - O35454
swissprot - Q3UM91
swissprot - A2A7F6
Ensembl - ENSMUSG00000029016
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clcn6ENSDARG00000032577Danio rerio
 CLCN6ENSGALG00000004590Gallus gallus
 CLCN6ENSG00000011021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clcn7 / O70496 / H(+)/Cl(-) exchange transporter 7 / P51798* / chloride voltage-gated channel 7*ENSMUSG0000003663639
Clcn5 / Q9WVD4 / H(+)/Cl(-) exchange transporter 5 / P51795* / chloride voltage-gated channel 5*ENSMUSG0000000431725
Clcn3 / P51791 / H(+)/Cl(-) exchange transporter 3 / P51790* / chloride voltage-gated channel 3*ENSMUSG0000000431925
Clcn4 / Q61418 / Mus musculus chloride channel, voltage-sensitive 4 (Clcn4), transcript variant 7, mRNA. / P51793* / chloride voltage-gated channel 4*ENSMUSG0000000060524
Clcn2 / Q9R0A1 / Chloride channel protein 2 / P51788* / chloride voltage-gated channel 2*ENSMUSG0000002284320
Clcn1 / Q64347 / Chloride channel protein 1 / P35523* / chloride voltage-gated channel 1*ENSMUSG0000002986220
Clcnka / Q9WUB7 / Chloride channel protein ClC-Ka / CLCNKB* / P51800* / P51801* / chloride voltage-gated channel Kb* / chloride voltage-gated channel Ka*ENSMUSG0000003377017
Q9WUB6 / Clcnkb / Chloride channel protein ClC-Kb / CLCNKA* / P51800* / P51801* / chloride voltage-gated channel Ka* / chloride voltage-gated channel Kb*ENSMUSG0000000621616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001807  Chloride channel, voltage gated
 IPR002248  Chloride channel ClC-6
 IPR014743  Chloride channel, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005247 voltage-gated chloride channel activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015297 antiporter activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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