ENSMUSG00000022843


Mus musculus

Features
Gene ID: ENSMUSG00000022843
  
Biological name :Clcn2
  
Synonyms : Chloride channel protein 2 / Clcn2 / Q9R0A1
  
Possible biological names infered from orthology : chloride voltage-gated channel 2 / P51788
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 20702964
Gene end: 20717746
  
Corresponding Affymetrix probe sets: 10438530 (MoGene1.0st)   1449248_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112759
Ensembl peptide - ENSMUSP00000122921
Ensembl peptide - ENSMUSP00000007207
NCBI entrez gene - 12724     See in Manteia.
MGI - MGI:105061
RefSeq - XM_006521749
RefSeq - XM_017316862
RefSeq - NM_009900
RefSeq Peptide - NP_034030
swissprot - Q9R0A1
swissprot - D6RFS3
swissprot - A9C437
Ensembl - ENSMUSG00000022843
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clcn2aENSDARG00000062427Danio rerio
 clcn2cENSDARG00000060439Danio rerio
 CLCN2ENSGALG00000025804Gallus gallus
 CLCN2ENSG00000114859Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clcn1 / Q64347 / Chloride channel protein 1 / P35523* / chloride voltage-gated channel 1*ENSMUSG0000002986252
Clcnka / Q9WUB7 / Chloride channel protein ClC-Ka / CLCNKB* / P51800* / P51801* / chloride voltage-gated channel Kb* / chloride voltage-gated channel Ka*ENSMUSG0000003377033
Q9WUB6 / Clcnkb / Chloride channel protein ClC-Kb / CLCNKA* / P51800* / P51801* / chloride voltage-gated channel Ka* / chloride voltage-gated channel Kb*ENSMUSG0000000621632
Clcn5 / Q9WVD4 / H(+)/Cl(-) exchange transporter 5 / P51795* / chloride voltage-gated channel 5*ENSMUSG0000000431721
Clcn4 / Q61418 / Mus musculus chloride channel, voltage-sensitive 4 (Clcn4), transcript variant 7, mRNA. / P51793* / chloride voltage-gated channel 4*ENSMUSG0000000060520
Clcn3 / P51791 / H(+)/Cl(-) exchange transporter 3 / P51790* / chloride voltage-gated channel 3*ENSMUSG0000000431920
Clcn7 / O70496 / H(+)/Cl(-) exchange transporter 7 / P51798* / chloride voltage-gated channel 7*ENSMUSG0000003663620
Clcn6 / O35454 / Chloride transport protein 6 / P51797* / chloride voltage-gated channel 6*ENSMUSG0000002901619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001807  Chloride channel, voltage gated
 IPR002244  Chloride channel ClC-2
 IPR014743  Chloride channel, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060689 cell differentiation involved in salivary gland development IMP
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005247 voltage-gated chloride channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm1.1Syc/Thrb+
Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Thrbtm1.1Syc/Thrb+
Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Thrbtm1.1Syc/Thrb+
Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Thrbtm1.1Syc/Thrb+
Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Thrbtm1.1Syc/Thrb+
Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss

Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Thrbtm1.1Syc/Thrb+
Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thrbtm1.1Syc/Thrb+
Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004109 abnormal Sertoli cell development "anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005310 abnormal salivary gland physiology "anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

Allelic Composition: Clcn2nmf289/Clcn2nmf289
Genetic Background: CByJ.Cg-Clcn2nmf289/Pjn

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn2tm1Mlv/Clcn2tm1Mlv
Genetic Background: involves: C57BL/6

 MP:0008581 disorganized photoreceptor inner segment "derangement of the pattern of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008917 abnormal oligodendrocyte physiology "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
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Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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