ENSMUSG00000033770


Mus musculus

Features
Gene ID: ENSMUSG00000033770
  
Biological name :Clcnka
  
Synonyms : Chloride channel protein ClC-Ka / Clcnka / Q9WUB7
  
Possible biological names infered from orthology : chloride voltage-gated channel Ka / chloride voltage-gated channel Kb / CLCNKB / P51800 / P51801
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 141384610
Gene end: 141398724
  
Corresponding Affymetrix probe sets: 10517901 (MoGene1.0st)   1450182_at (Mouse Genome 430 2.0 Array)   1455677_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122396
Ensembl peptide - ENSMUSP00000048520
Ensembl peptide - ENSMUSP00000101416
NCBI entrez gene - 12733     See in Manteia.
MGI - MGI:1329026
RefSeq - NM_001146307
RefSeq - NM_024412
RefSeq Peptide - NP_001139779
RefSeq Peptide - NP_077723
swissprot - A2ADB4
swissprot - Q9WUB7
Ensembl - ENSMUSG00000033770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clcnkENSDARG00000022560Danio rerio
 ENSGALG00000003713Gallus gallus
 CLCNKAENSG00000186510Homo sapiens
 CLCNKBENSG00000184908Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WUB6 / Clcnkb / Chloride channel protein ClC-Kb / CLCNKA* / P51800* / P51801* / chloride voltage-gated channel Ka* / chloride voltage-gated channel Kb*ENSMUSG0000000621684
Clcn2 / Q9R0A1 / Chloride channel protein 2 / P51788* / chloride voltage-gated channel 2*ENSMUSG0000002284343
Clcn1 / Q64347 / Chloride channel protein 1 / P35523* / chloride voltage-gated channel 1*ENSMUSG0000002986241
Clcn5 / Q9WVD4 / H(+)/Cl(-) exchange transporter 5 / P51795* / chloride voltage-gated channel 5*ENSMUSG0000000431724
Clcn7 / O70496 / H(+)/Cl(-) exchange transporter 7 / P51798* / chloride voltage-gated channel 7*ENSMUSG0000003663623
Clcn4 / Q61418 / Mus musculus chloride channel, voltage-sensitive 4 (Clcn4), transcript variant 7, mRNA. / P51793* / chloride voltage-gated channel 4*ENSMUSG0000000060523
Clcn3 / P51791 / H(+)/Cl(-) exchange transporter 3 / P51790* / chloride voltage-gated channel 3*ENSMUSG0000000431923
Clcn6 / O35454 / Chloride transport protein 6 / P51797* / chloride voltage-gated channel 6*ENSMUSG0000002901622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001807  Chloride channel, voltage gated
 IPR002250  Chloride channel ClC-K
 IPR014743  Chloride channel, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0050878 regulation of body fluid levels IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0072053 renal inner medulla development IMP
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0034707 chloride channel complex IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005247 voltage-gated chloride channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025418 Bsnd / Q8VIM4 / Barttin / Q8WZ55* / barttin CLCNK type accessory beta subunit*  / complex






 

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contact: otassy@igbmc.fr