ENSG00000011021


Homo sapiens

Features
Gene ID: ENSG00000011021
  
Biological name :CLCN6
  
Synonyms : chloride voltage-gated channel 6 / CLCN6 / P51797
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.22
Gene start: 11806096
Gene end: 11843144
  
Corresponding Affymetrix probe sets: 203950_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000234488
Ensembl peptide - ENSP00000308367
Ensembl peptide - ENSP00000365679
Ensembl peptide - ENSP00000365680
NCBI entrez gene - 1185     See in Manteia.
OMIM - 602726
RefSeq - NM_001256959
RefSeq - NM_001286
RefSeq Peptide - NP_001243888
RefSeq Peptide - NP_001277
swissprot - P51797
swissprot - Q5SNW4
Ensembl - ENSG00000011021
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clcn6ENSDARG00000032577Danio rerio
 CLCN6ENSGALG00000004590Gallus gallus
 Clcn6ENSMUSG00000029016Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLCN7 / P51798 / chloride voltage-gated channel 7ENSG0000010324939
CLCN3 / P51790 / chloride voltage-gated channel 3ENSG0000010957225
CLCN5 / P51795 / chloride voltage-gated channel 5ENSG0000017136524
CLCN4 / P51793 / chloride voltage-gated channel 4ENSG0000007346424
CLCN2 / P51788 / chloride voltage-gated channel 2ENSG0000011485920
CLCN1 / P35523 / chloride voltage-gated channel 1ENSG0000018803720
CLCNKA / P51800 / chloride voltage-gated channel KaENSG0000018651017
CLCNKB / P51801 / chloride voltage-gated channel KbENSG0000018490817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001807  Chloride channel, voltage gated
 IPR002248  Chloride channel ClC-6
 IPR014743  Chloride channel, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport NAS
 biological_processGO:0006884 cell volume homeostasis NAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005247 voltage-gated chloride channel activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015297 antiporter activity TAS


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Signaling by BRAF and RAF fusions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000011021 CLCN6 / P51797 / chloride voltage-gated channel 6  / complex






 

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