ENSG00000109572


Homo sapiens

Features
Gene ID: ENSG00000109572
  
Biological name :CLCN3
  
Synonyms : chloride voltage-gated channel 3 / CLCN3 / P51790
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q33
Gene start: 169612633
Gene end: 169723673
  
Corresponding Affymetrix probe sets: 201732_s_at (Human Genome U133 Plus 2.0 Array)   201733_at (Human Genome U133 Plus 2.0 Array)   201734_at (Human Genome U133 Plus 2.0 Array)   201735_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422678
Ensembl peptide - ENSP00000478336
Ensembl peptide - ENSP00000425823
Ensembl peptide - ENSP00000425323
Ensembl peptide - ENSP00000425160
Ensembl peptide - ENSP00000424603
Ensembl peptide - ENSP00000424540
Ensembl peptide - ENSP00000261514
Ensembl peptide - ENSP00000353857
NCBI entrez gene - 1182     See in Manteia.
OMIM - 600580
RefSeq - XM_011531586
RefSeq - NM_001243372
RefSeq - NM_001243374
RefSeq - NM_001829
RefSeq - NM_173872
RefSeq - XM_005262726
RefSeq Peptide - NP_001820
RefSeq Peptide - NP_776297
RefSeq Peptide - NP_001230301
RefSeq Peptide - NP_001230303
swissprot - D6RIX3
swissprot - H0Y8Z8
swissprot - D6RDZ6
swissprot - A0A0A0MTB7
swissprot - A0A087WU31
swissprot - P51790
swissprot - E9PE15
Ensembl - ENSG00000109572
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clcn3ENSDARG00000003269Danio rerio
 CLCN3ENSGALG00000009674Gallus gallus
 Clcn3ENSMUSG00000004319Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLCN4 / P51793 / chloride voltage-gated channel 4ENSG0000007346467
CLCN5 / P51795 / chloride voltage-gated channel 5ENSG0000017136567
CLCN7 / P51798 / chloride voltage-gated channel 7ENSG0000010324926
CLCN6 / P51797 / chloride voltage-gated channel 6ENSG0000001102125
CLCN2 / P51788 / chloride voltage-gated channel 2ENSG0000011485922
CLCN1 / P35523 / chloride voltage-gated channel 1ENSG0000018803721
CLCNKA / P51800 / chloride voltage-gated channel KaENSG0000018651018
CLCNKB / P51801 / chloride voltage-gated channel KbENSG0000018490818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001807  Chloride channel, voltage gated
 IPR002245  Chloride channel ClC-3
 IPR014743  Chloride channel, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0006885 regulation of pH TAS
 biological_processGO:0045794 negative regulation of cell volume IMP
 biological_processGO:0048388 endosomal lumen acidification TAS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface NAS
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0042581 specific granule IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005247 voltage-gated chloride channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0030165 PDZ domain binding IDA
 molecular_functionGO:0042803 protein homodimerization activity NAS
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0072320 volume-sensitive chloride channel activity IMP


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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