ENSMUSG00000001815


Mus musculus

Features
Gene ID: ENSMUSG00000001815
  
Biological name :Evx2
  
Synonyms : Evx2 / Homeobox even-skipped homolog protein 2 / P49749
  
Possible biological names infered from orthology : even-skipped homeobox 2 / Q03828
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 74652991
Gene end: 74659557
  
Corresponding Affymetrix probe sets: 10483789 (MoGene1.0st)   1421577_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001867
Ensembl peptide - ENSMUSP00000134131
NCBI entrez gene - 14029     See in Manteia.
MGI - MGI:95462
RefSeq - XM_006498729
RefSeq - NM_007967
RefSeq - XM_006498728
RefSeq Peptide - NP_031993
swissprot - P49749
swissprot - G5E813
Ensembl - ENSMUSG00000001815
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EVX2ENSGALG00000020768Gallus gallus
 EVX2ENSG00000174279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Evx1 / P23683 / Homeobox even-skipped homolog protein 1 / P49640* / even-skipped homeobox 1*ENSMUSG0000000550342
Mnx1 / Q9QZW9 / motor neuron and pancreas homeobox 1 / P50219*ENSMUSG0000000156615
Nkx1-1 / NK1 transcription factor-related protein 1 / Q15270* / NK1 homeobox 1*ENSMUSG0000002911212
Gbx1 / P82976 / Homeobox protein GBX-1 / Q14549* / gastrulation brain homeobox 1*ENSMUSG0000006772412
Gbx2 / P48031 / Homeobox protein GBX-2 / P52951* / gastrulation brain homeobox 2*ENSMUSG0000003448612
Nkx1-2 / P42580 / NK1 transcription factor-related protein 2 / Q9UD57* / NK1 homeobox 2*ENSMUSG0000004852811
Meox2 / P32443 / Homeobox protein MOX-2 / P50222* / mesenchyme homeobox 2*ENSMUSG0000003614411
Meox1 / P32442 / Homeobox protein MOX-1 / P50221* / mesenchyme homeobox 1*ENSMUSG0000000149310


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0035108 limb morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Evx2tm3Ddu/Evx2tm3Ddu,Hoxd13tm3Ddu/Hoxd13tm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Evx2tm3Ddu/Evx2tm3Ddu,Hoxd13tm3Ddu/Hoxd13tm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Evx2tm3Ddu/Evx2tm3Ddu,Hoxd13tm3Ddu/Hoxd13tm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Evx2tm3Ddu/Evx2tm3Ddu,Hoxd13tm3Ddu/Hoxd13tm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Evx2tm3Ddu/Evx2tm3Ddu,Hoxd13tm3Ddu/Hoxd13tm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Del(2Hoxd11-Hoxd13)29Ddu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Del(2Hoxd11-Hoxd13)29Ddu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0003073 abnormal metacarpal bone morphology "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Evx2tm3Ddu/Evx2tm3Ddu,Hoxd13tm3Ddu/Hoxd13tm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0004361 bowed ulna "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0004634 short metacarpal bones "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Evx2tm3Ddu/Evx2tm3Ddu,Hoxd13tm3Ddu/Hoxd13tm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm2Ddu/Evx2tm2Ddu,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Evx2tm1Ddu/Evx2tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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