Manteia

ENSMUSG00000034486

Mus musculus

Features

Gene ID:	ENSMUSG00000034486

Biological name :	Gbx2

Synonyms :	Gbx2 / Homeobox protein GBX-2 / P48031

Possible biological names infered from orthology :	gastrulation brain homeobox 2 / P52951

Species:	Mus musculus

Chr. number:	1
Strand:	-1
Band:	D
Gene start:	89927956
Gene end:	89931179

Corresponding Affymetrix probe sets:	10356484 (MoGene1.0st) 1420337_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000048508 NCBI entrez gene - 14472 See in Manteia. MGI - MGI:95668 RefSeq - NM_010262 RefSeq Peptide - NP_034392 swissprot - P48031 Ensembl - ENSMUSG00000034486

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gbx2	ENSDARG00000002933	Danio rerio
GBX2	ENSGALG00000013342	Gallus gallus
GBX2	ENSG00000168505	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gbx1 / P82976 / Homeobox protein GBX-1 / Q14549* / gastrulation brain homeobox 1*	ENSMUSG00000067724	51
Nkx1-1 / NK1 transcription factor-related protein 1 / Q15270* / NK1 homeobox 1*	ENSMUSG00000029112	21
Mnx1 / Q9QZW9 / motor neuron and pancreas homeobox 1 / P50219*	ENSMUSG00000001566	20
Meox1 / P32442 / Homeobox protein MOX-1 / P50221* / mesenchyme homeobox 1*	ENSMUSG00000001493	19
Nkx1-2 / P42580 / NK1 transcription factor-related protein 2 / Q9UD57* / NK1 homeobox 2*	ENSMUSG00000048528	18
Evx1 / P23683 / Homeobox even-skipped homolog protein 1 / P49640* / even-skipped homeobox 1*	ENSMUSG00000005503	17
Evx2 / P49749 / Homeobox even-skipped homolog protein 2 / Q03828* / even-skipped homeobox 2*	ENSMUSG00000001815	17
Meox2 / P32443 / Homeobox protein MOX-2 / P50222* / mesenchyme homeobox 2*	ENSMUSG00000036144	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site
IPR020479	Homeobox domain, metazoa
IPR031250	Homeobox protein GBX-2

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001569	branching involved in blood vessel morphogenesis	IMP
biological_process	GO:0001755	neural crest cell migration	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007411	axon guidance	IMP
biological_process	GO:0008283	cell proliferation	IMP
biological_process	GO:0021549	cerebellum development	IMP
biological_process	GO:0021555	midbrain-hindbrain boundary morphogenesis	IMP
biological_process	GO:0021568	rhombomere 2 development	IMP
biological_process	GO:0021794	thalamus development	IMP
biological_process	GO:0021884	forebrain neuron development	IMP
biological_process	GO:0021930	cerebellar granule cell precursor proliferation	IMP
biological_process	GO:0030902	hindbrain development	IMP
biological_process	GO:0030917	midbrain-hindbrain boundary development	IMP
biological_process	GO:0035239	tube morphogenesis	IMP
biological_process	GO:0042472	inner ear morphogenesis	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0048483	autonomic nervous system development	IMP
cellular_component	GO:0005634	nucleus	IDA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	IDA
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000018	small ears	"outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0000026	abnormal inner ear morphology	"malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Thoc1^tm1Dwg/Thoc1^tm2Dwg Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0000033	absent cochlear duct	"missing spiral tube within the cochlea; contains the neuroepithelial receptor organ for hearing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0000035	abnormal membranous labyrinth	"malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0000041	absent endolymphatic duct	"missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000273	overriding aorta	"congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0000704	abnormal thymus development	"anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0000776	abnormal inferior colliculus	"dysmorphology or disorganization of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000777	increased size of inferior colliculus	"enlargement of the paired inferior eminence of the mesencephalic tectum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57538]	Show Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0000820	abnormal choroid plexus morphology	"malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000832	abnormal thalamus morphology	"malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gbx2^{tm1.1(cre/ERT2)Jyhl}/Gbx2^tm1.1Mrt,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL Allelic Composition: Gbx2^{tm1.1(cre/ERT2)Jyhl}/Gbx2^tm1Mrt,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
MP:0000841	abnormal hindbrain morphology	"malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000847	abnormal metencephalon morphology	"any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0000848	abnormal pons	"malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0000850	absent cerebellum	"missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gbx2^{tm1.1(cre/ERT2)Jyhl}/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
MP:0000854	abnormal cerebellum development	"malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0000857	abnormal cerebellar foliation	"malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]	Show Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0000866	vermis hypoplasia	"reduced cell number in the vermis" [J:61509]	Show Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0000897	abnormal midbrain	"malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^tm1Pas/Otx2^tm2Asim Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0000934	abnormal telencephalon development	"malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]	Show Allelic Composition: Gbx2^{tm1.1(cre/ERT2)Jyhl}/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
MP:0000937	abnormal motor neuron morphology	"malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001066	absent trigeminal nerve	"missing chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:33038]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0001092	abnormal trigeminal ganglion morphology	"malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0001731	abnormal postnatal growth	"anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0002127	abnormal cardiovascular system morphology	"abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.2Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnmt1^tm2Jae/Dnmt1^tm2Jae,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Gbx2^tm1.1Alj/Gbx2^tm1.1Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0002184	abnormal innervation	"the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0002672	abnormal branchial arch artery morphology	"malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0002855	abnormal cochlear ganglion morphology	"malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0002950	abnormal neural crest cell migration	"defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0003146	absent cochlear ganglion	"absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [J:36834, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0003148	reduced cochlear coiling	"a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0003161	absent lateral semicircular canal		Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0003163	absent posterior semicircular canal		Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0003165	absent superior semicircular canal		Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003308	abnormal cochlear sensory epithelium		Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0003543	abnormal vascular endothelial cell differentiation	"anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.2Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0003661	abnormal locus ceruleus	"anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003740	fusion of middle ear ossicles	"union of the three small bones of the middle ear into a single structure " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0003864	abnormal midbrain development	"anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0003874	absent branchial arches	"missing the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0004096	abnormal midbrain-hindbrain boundary development	"anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004113	abnormal aortic arch morphology	"structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0004157	interrupted aortic arch	"complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0004160	retroesophageal right subclavian artery	"the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0004249	abnormal crista ampullaris morphology	"anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0004261	abnormal embryonic neuroepithelium morphology	"any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0004310	small otic vesicle	"reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0004315	absent saccule	"absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0004330	abnormal saccular macula morphology	"any structural abnormalities in the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0004443	absent supraoccipital bone	"absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004568	fusion of glossopharyngeal and vagus nerve	"union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0004592	small mandible	"reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Fgf8^tm1.4Mrt/Fgf8⁺ Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt
MP:0004923	absent common crus	"absence of the united, nonampullary ends of the superior and posterior semicircular ducts in the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0004937	dilated heart	"stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.2Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0005657	abnormal neural plate morphology	"malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0006108	abnormal hindbrain development	"anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0006287	inner ear cysts	"abnormal membranous sacs in any component of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:111415, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0006289	otic capsule hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the cartilage or bony capsule surrounding the inner ear mechanism" [J:100584, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0006293	absent olfactory placodes	"absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes " [J:71787, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0006294	absent optic vesicle	"absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0006354	abnormal fourth branchial arch artery morphology	"any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008023	abnormal styloid process morphology	"any structural abnormality in the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0009843	decreased neural crest cell number	"reduction in the number of ransient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0009845	abnormal neural crest cell morphology	"any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch,Slc6a4^tm1(cre)Grch/Slc6a4⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: B6.129-Gbx2^tm1.1Mrt
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.2Alj Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0012132	abnormal midbrain-hindbrain boundary morphology	"any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]	Show Allelic Composition: Gck^tm1Efr/Gck⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0012133	absent midbrain-hindbrain boundary	"absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0012170	absent optic placodes	"absence of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles" [MGI:anna]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0012176	abnormal head development	"anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^tm1Pas/Otx2^tm2Asim Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0012703	decreased embryonic neuroepithelium thickness	"reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]	Show Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0012706	decreased embryonic neuroepithelial cell proliferation	"decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]	Show Allelic Composition: En1^tm2(cre)Wrst/En1⁺,Gbx2^tm1.1Mrt/Gbx2^tm1.1Alj Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
MP:0012800	abnormal rhombomere 5 morphology	"any structural anomaly of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005515]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
MP:0013906	absent embryonic telencephalon	"absence of the paired diverticula of the embryonic telencephalon, from which the forebrain develops" [MGI:Anna]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt,Otx2^{tm1(OTX1)Asim}/Otx2^{tm1(OTX1)Asim} Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0030124	middle ear ossicle hypoplasia	"underdevelopment or reduced size of the three bones of the middle ear, usually due to reduced cell number" [MGI:anna]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: B6.129-Gbx2^tm1.1Mrt
MP:0030322	styloid process hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [MGI:anna]	Show Allelic Composition: Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Genetic Background: B6.129-Gbx2^tm1.1Mrt

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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