Manteia

ENSMUSG00000001493

Mus musculus

Features

Gene ID:	ENSMUSG00000001493

Biological name :	Meox1

Synonyms :	Homeobox protein MOX-1 / Meox1 / P32442

Possible biological names infered from orthology :	mesenchyme homeobox 1 / P50221

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	D
Gene start:	101877510
Gene end:	101894374

Corresponding Affymetrix probe sets:	10391504 (MoGene1.0st) 1417595_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000051158 NCBI entrez gene - 17285 See in Manteia. MGI - MGI:103220 RefSeq - NM_010791 RefSeq Peptide - NP_034921 swissprot - P32442 Ensembl - ENSMUSG00000001493

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
MEOX1	ENSG00000005102	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Meox2 / P32443 / Homeobox protein MOX-2 / P50222* / mesenchyme homeobox 2*	ENSMUSG00000036144	43
Gbx2 / P48031 / Homeobox protein GBX-2 / P52951* / gastrulation brain homeobox 2*	ENSMUSG00000034486	26
Gbx1 / P82976 / Homeobox protein GBX-1 / Q14549* / gastrulation brain homeobox 1*	ENSMUSG00000067724	25
Mnx1 / Q9QZW9 / motor neuron and pancreas homeobox 1 / P50219*	ENSMUSG00000001566	23
Nkx1-1 / NK1 transcription factor-related protein 1 / Q15270* / NK1 homeobox 1*	ENSMUSG00000029112	23
Evx1 / P23683 / Homeobox even-skipped homolog protein 1 / P49640* / even-skipped homeobox 1*	ENSMUSG00000005503	21
Nkx1-2 / P42580 / NK1 transcription factor-related protein 2 / Q9UD57* / NK1 homeobox 2*	ENSMUSG00000048528	21
Evx2 / P49749 / Homeobox even-skipped homolog protein 2 / Q03828* / even-skipped homeobox 2*	ENSMUSG00000001815	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site
IPR020479	Homeobox domain, metazoa

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001757	somite specification	IGI
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI
biological_process	GO:0060218	hematopoietic stem cell differentiation	ISS
biological_process	GO:0061053	somite development	IMP
biological_process	GO:0061056	sclerotome development	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001046	core promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IDA
molecular_function	GO:0043565	sequence-specific DNA binding	IMP
molecular_function	GO:0071837	HMG box domain binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^tm1Bmk/Meox1⁺,Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000138	absent vertebrae	"missing bony segments of the spinal column" [J:35802]	Show Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh},Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0000141	abnormal vertebral body morphology	"malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Meox1^tm1Bmk/Meox1^tm1Bmk,Meox2^tm1Vpa/Meox2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000151	absent rib	"missing the pairs of bony structures that make up the body wall" [J:19212]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh},Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0000154	rib fusion	"appearance of one or more ribs as a single structure" [J:62022, J:62023]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh} Genetic Background: involves: C3H/HeJ * C57BL/6 Allelic Composition: Meox1^tm1Bmk/Meox1^tm1Bmk,Meox2^tm1Vpa/Meox2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0000737	abnormal myotome development	"malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh},Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0000963	fused dorsal root ganglia	"loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001077	abnormal spinal nerve morphology	"any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh},Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh},Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0001691	abnormal somite shape	"atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001780	decreased brown fat amount	"reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^tm1Bmk/Meox1⁺,Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺,Meox1^tm1(cre)Jpa/Meox1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0002632	vestigial tail	"a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh},Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0002823	abnormal rib development	"anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh} Genetic Background: involves: C3H/HeJ * C57BL/6
MP:0003358	abnormal hypaxial muscle morphology	"malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0004206	abnormal dermomyotome development	"any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0004248	abnormal epaxial muscle morphology	"any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0004609	vertebral fusion	"the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh} Genetic Background: involves: C3H/HeJ * C57BL/6
MP:0004619	caudal vertebral fusion	"the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Meox1^tm1Bmk/Meox1⁺,Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Meox1^tm1Bmk/Meox1^tm1Bmk,Meox2^tm1Vpa/Meox2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004653	absent caudal vertebrae	"absence of all of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0004703	abnormal vertebral column	"any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0005222	abnormal somite size	"atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0005223	abnormal anterior-posterior polarity of the somites	"anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh} Genetic Background: involves: C3H/HeJ * C57BL/6 Allelic Composition: Meox1^tm1Bmk/Meox1^tm1Bmk,Meox2^tm1Vpa/Meox2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005421	loose skin	"condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0006029	abnormal sclerotome	"malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0008832	hemivertebra	"a congenital malformation of the spine in which only half of a vertebral body develops" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh} Genetic Background: involves: C3H/HeJ * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Meox1^{Tg(Mx1-TAX)2627Arnh}/Meox1^{Tg(Mx1-TAX)2627Arnh},Meox2^tm1Vpa/Meox2^tm1Vpa Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
MP:0030286	occipital bone hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the bone at the lower, posterior part of the skull" [MGI:anna]	Show Allelic Composition: Bmi1^tm1Brn/Bmi1⁺ Genetic Background: involves: 129P2/OlaHsd

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr