| MP:0000060 | delayed bone ossification | "late onset of the formation of bone" [J:40203] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
|
| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
|
| MP:0000066 | osteoporosis | "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
|
| MP:0000135 | reduced cortical bone thickness | "thinner than normal superficial layer of compact bone " [J:61509] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
|
| MP:0000137 | abnormal vertebrae morphology | "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox1tm1Bmk/Meox1+,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000138 | absent vertebrae | "missing bony segments of the spinal column" [J:35802] |
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Allelic Composition: Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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| MP:0000141 | abnormal vertebral body morphology | "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Meox1tm1Bmk/Meox1tm1Bmk,Meox2tm1Vpa/Meox2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000151 | absent rib | "missing the pairs of bony structures that make up the body wall" [J:19212] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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| MP:0000154 | rib fusion | "appearance of one or more ribs as a single structure" [J:62022, J:62023] |
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Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0000157 | abnormal sternum morphology | "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Slamf1tm1Oono/Slamf1tm1Oono
Genetic Background: B6.129-Slamf1tm1Oono Ifnar1tm1Agt
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Slamf1tm1Oono/Slamf1tm1Oono
Genetic Background: B6.129-Slamf1tm1Oono Ifnar1tm1Agt
|
| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
|
| MP:0000410 | waved hair | "hair or fur having undulations or a sinusoidal shape" [J:47620] |
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Allelic Composition: Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * FVB/N
|
| MP:0000440 | domed skull | |
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Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1
|
| MP:0000470 | abnormal stomach morphology | "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
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| MP:0000471 | abnormal stomach epithelium morphology | "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
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| MP:0000480 | increased number of ribs | "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
|
| MP:0000520 | absent kidney | "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
|
| MP:0000556 | abnormal hindlimb morphology | "malformation of the entire posterior extremities" [MGI:tc] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
|
| MP:0000562 | polydactyly | "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Efnb1tm1Sor/Y,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Efnb1tm1Sor/Efnb1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0000600 | liver hypoplasia | "reduced size of liver due to decreased cell number " [J:57631] |
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Allelic Composition: Krastm4.1Tyj/Kras+,Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J
|
| MP:0000630 | mammary gland hyperplasia | "increased size of mammary gland due to increased cell number" [J:63229] |
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Allelic Composition: Abcc6tm1Aabb/Abcc6tm1Aabb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000644 | dextrocardia | "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
|
| MP:0000729 | abnormal myogenesis | "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000733 | abnormal muscle development | "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000737 | abnormal myotome development | "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000747 | muscle weakness | "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
|
| MP:0000759 | abnormal skeletal muscle morphology | "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
Allelic Composition: Meox2fla/Meox2fla
Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000786 | abnormal neuroepithelial layer differentiation | "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
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| MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Snai1tm1Grid/Snai1tm2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor
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| MP:0000955 | abnormal spinal cord morphology | "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0000961 | abnormal dorsal root ganglia morphology | "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000963 | fused dorsal root ganglia | "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001053 | abnormal neuromuscular synapse | "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001077 | abnormal spinal nerve morphology | "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0001156 | abnormal spermatogenesis | "incomplete maturation or aberrant formation of the male gametes" [J:58959] |
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0001177 | atelectasis | "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0001178 | pulmonary hypoplasia | "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Trp53tm2.1Wgu/Trp53tm2.1Wgu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Reltm1Hcl/Rel+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0001360 | abnormal social investigation | "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001524 | impaired limb coordination | "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
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| MP:0001533 | abnormal skeleton physiology | "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm4.1Tyj/Kras+,Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Zfp568Gt(P103E09)Wrst/Zfp568Gt(RRU161)Byg,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
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| MP:0001688 | abnormal somite development | "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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| MP:0001691 | abnormal somite shape | "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0001705 | abnormal proximal-distal axis patterning | "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0001711 | abnormal placenta | |
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm2Ggg,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0001716 | abnormal placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pak4tm2.1Amin/Pak4tm2.2Amin
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0001718 | abnormal yolk sac | "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pak4tm2.1Amin/Pak4tm2.2Amin
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0001726 | abnormal allantois | "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622] |
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SD7
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0001780 | decreased brown fat amount | "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Pkd1tm1Ggg/Pkd1tm2Ggg,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0001917 | intraventricular hemorrhage | "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0001924 | infertility | "inability to produce live offspring" [J:47225] |
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0001953 | respiratory failure | "cessation of or failure to commence breathing" [MGI:cls, J:60159] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Pkd1tm1Ggg/Pkd1tm2Ggg,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0002058 | neonatal lethality | "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Atmtm1Pmc/Atm+
Genetic Background: B6.Cg-Atmtm1Pmc
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0002084 | abnormal developmental patterning | "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Xrcc1tm1Pmc/Xrcc1tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
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| MP:0002109 | abnormal limb morphology | "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0002114 | abnormal axial skeleton morphology | "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox1tm1Bmk/Meox1+,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm1Dcc/Mfn1tm2Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0002175 | low brain weight | "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0002231 | abnormal primitive streak morphology | "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0002264 | abnormal bronchus morphology | "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0002269 | muscular atrophy | "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0002396 | abnormal hematopoietic system morphology/development | "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J
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| MP:0002447 | abnormal erythrocyte morphology | "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0002591 | decreased mean corpuscular volume | "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0002632 | vestigial tail | "a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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| MP:0002640 | reticulocytosis | "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0002642 | anisocytosis | "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0002643 | poikilocytosis | "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2fla/Meox2fla
Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0002745 | abnormal atrioventricular valve morphology | "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0002764 | short tibia | " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0002766 | situs inversus | "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
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| MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0003036 | vertebral transformation | "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0003052 | omphalocele | "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
|
| MP:0003082 | abnormal gastrocnemius morphology | "anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2fla/Meox2fla
Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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| MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J
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| MP:0003231 | abnormal placental vasculature | "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157] |
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm2Ggg,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0003321 | tracheoesophageal fistula | "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0003335 | exocrine pancreatic insufficiency | "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0003336 | pancreatic cysts | "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0003358 | abnormal hypaxial muscle morphology | "malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0003456 | absent tail | "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
|
| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Pkd2tm1.1Tjwt/Pkd2tm1.2Tjwt,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Pkd1tm1Ggg/Pkd1tm2Ggg,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0003755 | abnormal palate | "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0003787 | abnormal imprinting | "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SD7
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| MP:0003861 | abnormal nervous system development | "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
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| MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0003891 | increased allantois apoptosis | "increase in the number of cells of the allantois undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0003958 | heart valve hyperplasia | "increased number of cells of the heart valves, leading to increased size or bulk" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:60214] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Snai1tm1Grid/Snai1tm2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor
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| MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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| MP:0004020 | polyhydramnios | "abnormally high amniotic fluid volume; may result from maternal diabetes, chromosomal abnormalities or other congenital abnormalities" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm2Ggg,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0004024 | aneuploidy | "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0004046 | abnormal mitosis | "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0004077 | abnormal striatum morphology | "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0004087 | abnormal muscle fiber morphology | "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0004110 | transposition of great arteries | "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0004190 | abnormal direction of embryo turning | "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"] |
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0004206 | abnormal dermomyotome development | "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004228 | decreased cellular sensitivity to ionizing radiation | "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atrtm2Bal/Atrtm2Bal,Cdkn2atm2Brn/Cdkn2atm2Brn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
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| MP:0004229 | abnormal embryonic erythropoiesis | "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0004230 | abnormal embryonic erythrocyte morphology | "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0004248 | abnormal epaxial muscle morphology | "any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004252 | abnormal direction of looping morphogenesis | "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0004263 | abnormal limb posture | "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0004619 | caudal vertebral fusion | "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox1tm1Bmk/Meox1+,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Meox1tm1Bmk/Meox1tm1Bmk,Meox2tm1Vpa/Meox2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0004653 | absent caudal vertebrae | "absence of all of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004703 | abnormal vertebral column | "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0004756 | abnormal proximal convoluted tubule morphology | "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0004760 | increased mitotic index | "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG] |
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0004819 | decreased skeletal muscle mass | "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0004948 | abnormal neuronal precursor proliferation | "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0004950 | abnormal brain vasculature | "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0004980 | increased neuronal precursor cell number | "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004991 | decreased bone strength | "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004993 | decreased bone resorption | "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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| MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Slamf1tm1Oono/Slamf1tm1Oono
Genetic Background: B6.129-Slamf1tm1Oono Ifnar1tm1Agt
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| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0005155 | herniated intestine | "protrusion of any portion of the intestine from its normal anatomical position" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0005222 | abnormal somite size | "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005223 | abnormal anterior-posterior polarity of the somites | "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body
" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005225 | abnormal vertebrae development | "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Meox1tm1Bmk/Meox1tm1Bmk,Meox2tm1Vpa/Meox2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005406 | abnormal heart size | "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Slamf1tm1Oono/Slamf1tm1Oono
Genetic Background: B6.129-Slamf1tm1Oono Ifnar1tm1Agt
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| MP:0005421 | loose skin | "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005481 | chronic myelocytic leukemia | "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0005508 | abnormal skeleton morphology | "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0005562 | decreased mean corpuscular hemoglobin | "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0006029 | abnormal sclerotome | "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0006107 | abnormal atrioventricular canal morphology | "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610] |
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0006322 | abnormal perichondrium morphology | "any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", J:117033, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Efnb1tm1Sor/Efnb1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0006362 | abnormal male germ cell morphology | "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0006378 | abnormal spermatogonia morphology | "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0006379 | abnormal spermatocyte morphology | "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0006380 | abnormal spermatid morphology | "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0008069 | abnormal joint mobility | "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2fla/Meox2fla
Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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| MP:0008143 | abnormal dendrite morphology | "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0008146 | asymmetric rib-sternum attachment | "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0008148 | abnormal rib-sternum attachment | "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0008257 | thin myometrium | "reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2fla/Meox2fla
Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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| MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0008390 | abnormal primordial germ cell proliferation | "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0008393 | absent primordial germ cells | "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0008396 | abnormal osteoclast differentiation | "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0008738 | abnormal liver iron level | "anomaly in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008809 | increased spleen iron level | "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0009146 | abnormal pancreatic acinar cell morphology | "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0009247 | meteorism | "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
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| MP:0009403 | increased variability of skeletal muscle fiber size | "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009404 | centrally nucleated skeletal muscle fibers | "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009890 | cleft secondary palate | "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009936 | abnormal dendritic spine morphology | "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0010107 | abnormal renal reabsorption | "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
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| MP:0010212 | abnormal circulating C-reactive protein level | "deviation from the normal levels of the plasma protein that circulates in increased amounts during inflammation or after tissue damage and binds to phosphocholine expressed on the surface of dead or dying cells, including all types of pneumococci, in order to activate the complement system via the C1Q complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D12.776.034.145, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J
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| MP:0010213 | abnormal circulating fibrinogen level | "deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J
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| MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Abcc6tm1Aabb/Abcc6tm1Aabb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Ets2tm3Rgo/Ets2+,Meox2tm1(cre)Sor/?,Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/?,Tg(MMTV-cre)7Mul/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N
Allelic Composition: Ets2tm3Rgo/Ets2+,Meox2tm1(cre)Sor/?,Tg(MMTV-cre)7Mul/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0010466 | vascular ring | "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0010588 | conotruncal ridge hyperplasia | "overdevelopment or increased size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0010769 | abnormal survival | "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Faslpr/Fas+,Tg(TcraTcrb)1100Mjb/?
Genetic Background: involves: C57BL/6 * MRL/Mp
Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc
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| MP:0010779 | abnormal stomach muscularis externa morphology | "any structural anomaly of the smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
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| MP:0010856 | dilated respiratory conducting tubes | "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011024 | abnormal branching involved in lung morphogenesis | "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011028 | impaired branching involved in bronchus morphogenesis | |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Krastm4Tyj/Kras+,Spry2tm1.1Mrt/Spry2tm1.1Mrt,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N
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| MP:0011032 | impaired branching involved in terminal bronchiole morphogenesis | |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011083 | complete lethality at weaning | "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith] |
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Efnb1tm1Sor/Y,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Efnb1tm1Sor/Efnb1tm1Sor,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Efnb1tm1Sor/Efnb1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Meox1Tg(Mx1-TAX)2627Arnh/Meox1Tg(Mx1-TAX)2627Arnh,Meox2tm1Vpa/Meox2tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm3Dcc/Mfn2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm1Dcc/Mfn1tm2Dcc,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Zfxtm1.1Reiz/Y,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Zfxtm1.1Reiz/Zfxtm1.1Reiz,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Pkd1tm1Ggg/Pkd1tm2Ggg,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn1tm2Dcc/Mfn1+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss
Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Procrtm1Cte/Procrtm2Cte
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6
Allelic Composition: Ets2tm2Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Nrastm1Tyj/Nras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0011094 | complete embryonic lethality before implantation | "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0011097 | complete embryonic lethality before turning of embryo | "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith] |
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Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Mecp2tm2Bird/Mecp2+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Snai1tm1Grid/Snai1tm2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor
Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Xrcc1tm1Pmc/Xrcc1tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Sec24ctm1c(EUCOMM)Wtsi/Sec24ctm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Krastm4Tyj/Kras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Pkd1tm1Ggg/Pkd1tm2Ggg,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0011227 | abnormal vitamin B12 level | "any anomaly in the concentration of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom" [GO:0009236] |
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Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
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| MP:0011411 | abnormal gonadal ridge morphology | "any structural anomaly of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary" [MGI:anna] |
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0012157 | rostral body truncation | "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0012676 | dilated brain ventricles | "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna] |
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Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J
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| MP:0013504 | increased embryonic tissue cell apoptosis | "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Xrcc1tm1Pmc/Xrcc1tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
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| MP:0014185 | cerebellum atrophy | "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
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| MP:0020369 | increased intestinal iron level | "increase in the amount of iron present in the large or small intestinal tissue" [MGI:Anna] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
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| MP:0030286 | occipital bone hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the bone at the lower, posterior part of the skull" [MGI:anna] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd
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