ENSMUSG00000067724


Mus musculus

Features
Gene ID: ENSMUSG00000067724
  
Biological name :Gbx1
  
Synonyms : Gbx1 / Homeobox protein GBX-1 / P82976
  
Possible biological names infered from orthology : gastrulation brain homeobox 1 / Q14549
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 24502757
Gene end: 24527202
  
Corresponding Affymetrix probe sets: 10528617 (MoGene1.0st)   1456760_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085651
NCBI entrez gene - 231044     See in Manteia.
MGI - MGI:95667
RefSeq - NM_015739
RefSeq Peptide - NP_056554
swissprot - P82976
Ensembl - ENSMUSG00000067724
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gbx1ENSDARG00000071418Danio rerio
 GBX1ENSGALG00000042241Gallus gallus
 GBX1ENSG00000164900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gbx2 / P48031 / Homeobox protein GBX-2 / P52951* / gastrulation brain homeobox 2*ENSMUSG0000003448642
Mnx1 / Q9QZW9 / motor neuron and pancreas homeobox 1 / P50219*ENSMUSG0000000156620
Nkx1-1 / NK1 transcription factor-related protein 1 / Q15270* / NK1 homeobox 1*ENSMUSG0000002911217
Nkx1-2 / P42580 / NK1 transcription factor-related protein 2 / Q9UD57* / NK1 homeobox 2*ENSMUSG0000004852815
Meox1 / P32442 / Homeobox protein MOX-1 / P50221* / mesenchyme homeobox 1*ENSMUSG0000000149315
Evx1 / P23683 / Homeobox even-skipped homolog protein 1 / P49640* / even-skipped homeobox 1*ENSMUSG0000000550314
Evx2 / P49749 / Homeobox even-skipped homolog protein 2 / Q03828* / even-skipped homeobox 2*ENSMUSG0000000181513
Meox2 / P32443 / Homeobox protein MOX-2 / P50222* / mesenchyme homeobox 2*ENSMUSG0000003614413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR031251  Homeobox protein GBX-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0019230 proprioception IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0097374 sensory neuron axon guidance IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1Rha
Genetic Background: B6.129P2-Jam3tm1Rha

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Hand1tm2.1Jcc/Hand1tm2.1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1Rha
Genetic Background: B6.129P2-Jam3tm1Rha

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Hand1tm2.1Jcc/Hand1tm2.1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand1tm2.1Jcc/Hand1tm2.1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1Rha
Genetic Background: B6.129P2-Jam3tm1Rha

Allelic Composition: Gbx1tm1Mrh/Gbx1tm1Mrh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Gbx1tm1Mrh/Gbx1tm1Mrh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1Rha
Genetic Background: B6.129P2-Jam3tm1Rha

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gbx1tm1Mrh/Gbx1tm1Mrh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gbx1tm1Mrh/Gbx1tm1Mrh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1Rha
Genetic Background: B6.129P2-Jam3tm1Rha

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0011994 increased nerve conduction velocity "increase in the rate at which an electrical impulse travels through a nerve" [MGI:csmith]
Show

Allelic Composition: Gbx1tm1Mrh/Gbx1tm1Mrh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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