ENSDARG00000071418


Danio rerio

Features
Gene ID: ENSDARG00000071418
  
Biological name :gbx1
  
Synonyms : gastrulation brain homeobox 1 / gbx1
  
Possible biological names infered from orthology : Homeobox protein GBX-1 / P82976 / Q14549
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 34113424
Gene end: 34116526
  
Corresponding Affymetrix probe sets: Dr.13338.1.S1_at (Zebrafish Array)   NM_174861_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000096349
NCBI entrez gene - 142985     See in Manteia.
RefSeq - NM_174861
RefSeq Peptide - NP_777286
swissprot - Q90ZB2
ZFIN ID - ZDB-GENE-020117-2
Ensembl - ENSDARG00000071418
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GBX1ENSGALG00000042241Gallus gallus
 GBX1ENSG00000164900Homo sapiens
 Gbx1ENSMUSG00000067724Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gbx2 / gastrulation brain homeobox 2 / P48031* / P52951* / Homeobox protein GBX-2 *ENSDARG0000000293352
mnx1 / motor neuron and pancreas homeobox 1 / P50219* / Q9QZW9*ENSDARG0000003598421
mnx2b / motor neuron and pancreas homeobox 2bENSDARG0000003035020
nkx1.2lb / NK1 transcription factor related 2-like,b / Q15270* / NKX1-1* / NK1 homeobox 1* / NK1 transcription factor-related protein 1 *ENSDARG0000009942718
mnx2a / motor neuron and pancreas homeobox 2aENSDARG0000004210618
meox2a / mesenchyme homeobox 2a / MEOX2* / P50222* / P32443* / mesenchyme homeobox 2* / Homeobox protein MOX-2 *ENSDARG0000004091117
vox / ventral homeobox / VENTX* / O95231* / VENT homeobox*ENSDARG0000009976116
meox2b / mesenchyme homeobox 2b / MEOX2* / P50222* / P32443* / mesenchyme homeobox 2* / Homeobox protein MOX-2 *ENSDARG0000006181816
evx1 / even-skipped homeobox 1 / P23683* / P49640* / Homeobox even-skipped homolog protein 1 *ENSDARG0000010008716
pnx / F1R2J1 / posterior neuron-specific homeoboxENSDARG0000002589916
nkx1.2la / NK1 transcription factor related 2-like,a / Q9UD57* / NKX1-2* / P42580* / NK1 homeobox 2* / NK1 transcription factor-related protein 2 *ENSDARG0000000635015
evx2 / even-skipped homeobox 2ENSDARG0000005925515
meox1 / F1Q4R9 / mesenchyme homeobox 1ENSDARG0000000789115
ved / ventrally expressed dharma/bozozok antagonistENSDARG0000010238913
vent / ventral expressed homeobox / VENTX* / O95231* / VENT homeobox*ENSDARG0000010048313
eve1 / even-skipped-like1ENSDARG0000005601212
evx1 / even-skipped homeobox 1 / P23683* / P49640* / Homeobox even-skipped homolog protein 1 *ENSDARG0000009936512


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR031251  Homeobox protein GBX-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021549 cerebellum development IGI
 biological_processGO:0021555 midbrain-hindbrain boundary morphogenesis IMP
 biological_processGO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
Show

 ZFA:0000029 hindbrain hindbrain anterior-posterior axis decreased length , abnormal
hindbrain anterior region decreased size , abnormal
Show

 ZFA:0000075 spinal cord spinal cord decreased length , abnormal
Show

 ZFA:0000131 neural keel neural keel wholly anterioralized , abnormal
Show

 ZFA:0000132 neural plate neural plate wholly anterioralized , abnormal
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 ZFA:0001094 whole organism whole organism necrotic , abnormal
whole organism shape , abnormal
Show

 ZFA:0007028 spinal cord neural keel spinal cord neural keel decreased length , abnormal
Show

 ZFA:0007044 midbrain hindbrain boundary neural plate midbrain hindbrain boundary neural plate mislocalised posteriorly , abnormal
Show

 ZFA:0007045 midbrain hindbrain boundary neural keel midbrain hindbrain boundary neural keel morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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