ENSDARG00000002933


Danio rerio

Features
Gene ID: ENSDARG00000002933
  
Biological name :gbx2
  
Synonyms : gastrulation brain homeobox 2 / gbx2
  
Possible biological names infered from orthology : Homeobox protein GBX-2 / P48031 / P52951
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 16031189
Gene end: 16034286
  
Corresponding Affymetrix probe sets: Dr.17548.1.S1_at (Zebrafish Array)   NM_152964_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000004972
NCBI entrez gene - 245948     See in Manteia.
RefSeq - NM_152964
RefSeq Peptide - NP_694496
swissprot - Q8QGU1
ZFIN ID - ZDB-GENE-020509-2
Ensembl - ENSDARG00000002933
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GBX2ENSGALG00000013342Gallus gallus
 GBX2ENSG00000168505Homo sapiens
 Gbx2ENSMUSG00000034486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gbx1 / gastrulation brain homeobox 1 / P82976* / Q14549* / Homeobox protein GBX-1 *ENSDARG0000007141848
mnx1 / motor neuron and pancreas homeobox 1 / P50219* / Q9QZW9*ENSDARG0000003598418
mnx2b / motor neuron and pancreas homeobox 2bENSDARG0000003035017
mnx2a / motor neuron and pancreas homeobox 2aENSDARG0000004210617
meox2b / mesenchyme homeobox 2b / MEOX2* / P50222* / P32443* / mesenchyme homeobox 2* / Homeobox protein MOX-2 *ENSDARG0000006181816
vox / ventral homeobox / VENTX* / O95231* / VENT homeobox*ENSDARG0000009976115
meox1 / F1Q4R9 / mesenchyme homeobox 1ENSDARG0000000789115
meox2a / mesenchyme homeobox 2a / MEOX2* / P50222* / P32443* / mesenchyme homeobox 2* / Homeobox protein MOX-2 *ENSDARG0000004091115
nkx1.2lb / NK1 transcription factor related 2-like,b / Q15270* / NKX1-1* / NK1 homeobox 1* / NK1 transcription factor-related protein 1 *ENSDARG0000009942715
nkx1.2la / NK1 transcription factor related 2-like,a / Q9UD57* / NKX1-2* / P42580* / NK1 homeobox 2* / NK1 transcription factor-related protein 2 *ENSDARG0000000635014
pnx / F1R2J1 / posterior neuron-specific homeoboxENSDARG0000002589914
evx2 / even-skipped homeobox 2ENSDARG0000005925513
evx1 / even-skipped homeobox 1 / P23683* / P49640* / Homeobox even-skipped homolog protein 1 *ENSDARG0000010008713
evx1 / even-skipped homeobox 1 / P23683* / P49640* / Homeobox even-skipped homolog protein 1 *ENSDARG0000009936512
vent / ventral expressed homeobox / VENTX* / O95231* / VENT homeobox*ENSDARG0000010048312
ved / ventrally expressed dharma/bozozok antagonistENSDARG0000010238911
eve1 / even-skipped-like1ENSDARG0000005601210


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021549 cerebellum development IGI
 biological_processGO:0030902 hindbrain development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain anterior region truncated , abnormal
Show

 ZFA:0000100 cerebellum cerebellum aplastic , abnormal
Show

 ZFA:0000697 cranial nerve V cranial nerve V neuronal cell body position , abnormal
cranial nerve V motor neuron disorganized , abnormal
Show

 ZFA:0000822 rhombomere 2 rhombomere 2 apoptotic , abnormal
Show

 ZFA:0000823 rhombomere 5 rhombomere 5 apoptotic , abnormal
Show

 ZFA:0000948 rhombomere 3 rhombomere 3 apoptotic , abnormal
rhombomere 3 decreased width , abnormal
Show

 ZFA:0001032 rhombomere 4 rhombomere 4 apoptotic , abnormal
Show

 ZFA:0007025 midbrain neural keel midbrain neural keel increased distribution , abnormal
Show

 ZFA:0007039 midbrain neural tube midbrain neural tube decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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