ENSDARG00000035984


Danio rerio

Features
Gene ID: ENSDARG00000035984
  
Biological name :mnx1
  
Synonyms : mnx1 / motor neuron and pancreas homeobox 1
  
Possible biological names infered from orthology : P50219 / Q9QZW9
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 40638210
Gene end: 40641006
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000052235
NCBI entrez gene - 405399     See in Manteia.
RefSeq - NM_001009885
RefSeq Peptide - NP_001009885
swissprot - Q6SYZ1
ZFIN ID - ZDB-GENE-040409-1
Ensembl - ENSDARG00000035984
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MNX1ENSGALG00000041154Gallus gallus
 MNX1ENSG00000130675Homo sapiens
 Mnx1ENSMUSG00000001566Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mnx2b / motor neuron and pancreas homeobox 2bENSDARG0000003035045
mnx2a / motor neuron and pancreas homeobox 2aENSDARG0000004210642
gbx1 / gastrulation brain homeobox 1 / P82976* / Q14549* / Homeobox protein GBX-1 *ENSDARG0000007141821
gbx2 / gastrulation brain homeobox 2 / P48031* / P52951* / Homeobox protein GBX-2 *ENSDARG0000000293320
evx2 / even-skipped homeobox 2ENSDARG0000005925518
meox2a / mesenchyme homeobox 2a / MEOX2* / P50222* / P32443* / mesenchyme homeobox 2* / Homeobox protein MOX-2 *ENSDARG0000004091118
meox2b / mesenchyme homeobox 2b / MEOX2* / P50222* / P32443* / mesenchyme homeobox 2* / Homeobox protein MOX-2 *ENSDARG0000006181818
vox / ventral homeobox / VENTX* / O95231* / VENT homeobox*ENSDARG0000009976117
evx1 / even-skipped homeobox 1 / P23683* / P49640* / Homeobox even-skipped homolog protein 1 *ENSDARG0000010008717
nkx1.2lb / NK1 transcription factor related 2-like,b / Q15270* / NKX1-1* / NK1 homeobox 1* / NK1 transcription factor-related protein 1 *ENSDARG0000009942716
ved / ventrally expressed dharma/bozozok antagonistENSDARG0000010238915
evx1 / even-skipped homeobox 1 / P23683* / P49640* / Homeobox even-skipped homolog protein 1 *ENSDARG0000009936515
nkx1.2la / NK1 transcription factor related 2-like,a / Q9UD57* / NKX1-2* / P42580* / NK1 homeobox 2* / NK1 transcription factor-related protein 2 *ENSDARG0000000635015
meox1 / F1Q4R9 / mesenchyme homeobox 1ENSDARG0000000789114
pnx / F1R2J1 / posterior neuron-specific homeoboxENSDARG0000002589914
eve1 / even-skipped-like1ENSDARG0000005601213
vent / ventral expressed homeobox / VENTX* / O95231* / VENT homeobox*ENSDARG0000010048312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003309 type B pancreatic cell differentiation IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IGI
 biological_processGO:0031018 endocrine pancreas development IGI
 biological_processGO:0048812 neuron projection morphogenesis IBA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000140 pancreas pancreas posterior region has extra parts of type endocrine cell , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas has fewer parts of type pancreatic B cell , abnormal
endocrine pancreas has extra parts of type pancreatic A cell , abnormal
endocrine pancreas decreased size , abnormal
Show

 ZFA:0001370 posterior pancreatic bud posterior pancreatic bud has fewer parts of type pancreatic B cell , abnormal
posterior pancreatic bud has extra parts of type pancreatic A cell , abnormal
posterior pancreatic bud decreased size , abnormal
Show

 ZFA:0005346 extrapancreatic duct extrapancreatic duct endocrine cell decreased amount , abnormal
Show

 ZFA:0005754 primary islet primary islet decreased size , abnormal
Show

 ZFA:0009102 pancreatic B cell pancreatic B cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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