ENSMUSG00000004937


Mus musculus

Features
Gene ID: ENSMUSG00000004937
  
Biological name :Sgta
  
Synonyms : Q8BJU0 / Sgta / small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
  
Possible biological names infered from orthology : O43765 / small glutamine rich tetratricopeptide repeat containing alpha
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 81044075
Gene end: 81060181
  
Corresponding Affymetrix probe sets: 10371041 (MoGene1.0st)   1451067_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151949
Ensembl peptide - ENSMUSP00000005067
Ensembl peptide - ENSMUSP00000151345
Ensembl peptide - ENSMUSP00000151678
NCBI entrez gene - 52551     See in Manteia.
MGI - MGI:1098703
RefSeq - XM_017314029
RefSeq - NM_001358550
RefSeq - NM_024499
RefSeq - XM_006513876
RefSeq - XM_006513877
RefSeq Peptide - NP_078775
RefSeq Peptide - NP_001345479
RefSeq Peptide - NP_001345478
swissprot - A0A1W2P6P1
swissprot - A0A1W2P7I5
swissprot - Q3TN35
swissprot - Q8BJU0
Ensembl - ENSMUSG00000004937
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgtaENSDARG00000019941Danio rerio
 SGTAENSGALG00000014067Gallus gallus
 SGTAENSG00000104969Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgtb / Q8VD33 / Small glutamine-rich tetratricopeptide repeat-containing protein beta / Q96EQ0* / small glutamine rich tetratricopeptide repeat containing beta*ENSMUSG0000004274356
Ttc12 / Q8BW49 / tetratricopeptide repeat domain 12 / Q9H892*ENSMUSG0000004021919
Stub1 / Q9WUD1 / STIP1 homology and U-Box containing protein 1 / Q9UNE7*ENSMUSG0000003961510


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR032374  SGTA, homodimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway ISS
 biological_processGO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process ISO
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043621 protein self-association ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:1904288 BAT3 complex binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0002717 abnormal preputial gland morphology "anomalous structure of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0003599 large penis "enlarged size of the organ of copulation and urination in the male" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

Allelic Composition: Sgtatm1.1Drmcr/Sgta+
Genetic Background: involves: C57BL/6

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

Allelic Composition: Sgtatm1.1Drmcr/Sgta+
Genetic Background: involves: C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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