ENSMUSG00000006611


Mus musculus

Features
Gene ID: ENSMUSG00000006611
  
Biological name :Hfe
  
Synonyms : Hereditary hemochromatosis protein homolog / Hfe / P70387
  
Possible biological names infered from orthology : hemochromatosis / Q30201
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 23702034
Gene end: 23710854
  
Corresponding Affymetrix probe sets: 10408227 (MoGene1.0st)   1422645_at (Mouse Genome 430 2.0 Array)   1450702_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006787
Ensembl peptide - ENSMUSP00000089298
Ensembl peptide - ENSMUSP00000089299
Ensembl peptide - ENSMUSP00000116569
NCBI entrez gene - 15216     See in Manteia.
MGI - MGI:109191
RefSeq - XM_011244284
RefSeq - NM_010424
RefSeq - XM_006516556
RefSeq - XM_006516557
RefSeq Peptide - NP_001334422
RefSeq Peptide - NP_034554
swissprot - P70387
swissprot - Q5SZ87
swissprot - Q5SZ91
swissprot - F7CW53
Ensembl - ENSMUSG00000006611
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR339041.1ENSDARG00000051710Danio rerio
 CR339041.2ENSDARG00000051711Danio rerio
 CR339041.3ENSDARG00000115781Danio rerio
 FO904903.1ENSDARG00000059039Danio rerio
 mhc1laaENSDARG00000016056Danio rerio
 mhc1lbaENSDARG00000016227Danio rerio
 mhc1ldaENSDARG00000023203Danio rerio
 mhc1lfaENSDARG00000051712Danio rerio
 mhc1lgaENSDARG00000051713Danio rerio
 mhc1liaENSDARG00000097766Danio rerio
 mhc1ljaENSDARG00000096830Danio rerio
 mhc1llaENSDARG00000096977Danio rerio
 mhc1ubaENSDARG00000075963Danio rerio
 mhc1ukaENSDARG00000092731Danio rerio
 mhc1umaENSDARG00000039164Danio rerio
 si:ch211-147g22.4ENSDARG00000097275Danio rerio
 si:dkey-225f5.5ENSDARG00000055813Danio rerio
 si:dkey-52p2.5ENSDARG00000096940Danio rerio
 HFEENSG00000010704Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mr1 / Q8HWB0 / major histocompatibility complex, class I-related / Q95460*ENSMUSG0000002647130
H2-T24ENSMUSG0000005383529
H2-M10.1ENSMUSG0000002444829
Azgp1 / Q64726 / Zinc-alpha-2-glycoprotein / P25311* / alpha-2-glycoprotein 1, zinc-binding*ENSMUSG0000003705329
H2-M10.6 / histocompatibility 2, M region locus 10.6ENSMUSG0000003713028
H2-M10.3ENSMUSG0000005812428
H2-M10.5ENSMUSG0000003724627
H2-M10.2 / histocompatibility 2, M region locus 10.2ENSMUSG0000002308327
H2-T10 / histocompatibility 2, T region locus 10ENSMUSG0000007949127
H2-M10.4ENSMUSG0000004823126
H2-T22 / histocompatibility 2, T region locus 22ENSMUSG0000005611626
Fcgrt / Q61559 / Mus musculus Fc receptor, IgG, alpha chain transporter (Fcgrt), transcript variant 2, mRNA. / P55899* / Fc fragment of IgG receptor and transporter*ENSMUSG0000000342026
Mill1 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*ENSMUSG0000005400526
Mill2 / MHC I like leukocyte 2 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*ENSMUSG0000004098725
2410137M14Rik / RIKEN cDNA 2410137M14 geneENSMUSG0000006430812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001039  MHC class I alpha chain, alpha1 alpha2 domains
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR031092  Hereditary hemochromatosis protein
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002626 negative regulation of T cell antigen processing and presentation IEA
 biological_processGO:0002725 negative regulation of T cell cytokine production IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010106 cellular response to iron ion starvation IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IC
 biological_processGO:0042446 hormone biosynthetic process IMP
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0055072 iron ion homeostasis ISO
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IMP
 biological_processGO:0071281 cellular response to iron ion IEA
 biological_processGO:0090277 positive regulation of peptide hormone secretion IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:0098711 iron ion import across plasma membrane IEA
 biological_processGO:1900121 negative regulation of receptor binding IEA
 biological_processGO:1900122 positive regulation of receptor binding IEA
 biological_processGO:1900390 regulation of iron ion import IEA
 biological_processGO:1904283 negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:1904434 positive regulation of ferrous iron binding IEA
 biological_processGO:1904437 positive regulation of transferrin receptor binding IEA
 biological_processGO:1904440 positive regulation of ferrous iron import across plasma membrane ISO
 biological_processGO:1990641 response to iron ion starvation IEA
 biological_processGO:2000008 regulation of protein localization to cell surface IEA
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IEA
 biological_processGO:2000272 negative regulation of signaling receptor activity IEA
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 biological_processGO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045178 basal part of cell IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:1990357 terminal web IEA
 cellular_componentGO:1990712 HFE-transferrin receptor complex IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0030881 beta-2-microglobulin binding IEA
 molecular_functionGO:0039706 co-receptor binding IEA
 molecular_functionGO:1990459 transferrin receptor binding IEA


Pathways (from Reactome)
Pathway description
Transferrin endocytosis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0000771 abnormal brain size "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001492 piloerection "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc11a2tm1Nca/Slc11a2+
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002980 abnormal postural reflex "failure to respond with the normal extension of legs to maintain balance when the cage is tilted" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88306]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Hfetm1.1Jrco/Hfe+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004147 increased porphyrin level "elevated concentration of porphyrins or protoporphyrins" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Gpr161vl/Gpr161vl
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

Allelic Composition: Hfetm1Gfn/Hfetm1Gfn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005638 hemochromatosis "disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:64456]
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Allelic Composition: Map2k6tm1Ina/Map2k6tm1Ina,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Hfetm1Gfn/?,Hfem1C57BL/6/Hfem1DBA/2
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Hfetm1Gfn/?,Hfem2DBA/2/Hfem2DBA/2
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Hfetm1Gfn/?,Hfem2C57BL/6/Hfem2DBA/2
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Hfetm1Gfn/?,Hfem3DBA/2/Hfem3DBA/2
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Hfetm1Gfn/?,Hfem4C57BL/6/Hfem4DBA/2
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Hfetm1Gfn/?,Hfem4DBA/2/Hfem4DBA/2
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: CpR435X/CpR435X,Hfetm1Sly/Hfetm1Sly
Genetic Background: involves: C3H/DiSnA * C57BL/10ScSnA

Allelic Composition: Hfetm1.1Wsr/Hfetm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm1Wsr/Hfetm1Wsr,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008743 decreased liver iron level "reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Tg(Ttr-Hfe)1Nca/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm2Nca/Hfe+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hephsla/Hephsla,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Tfrctm1Nca/Tfrc+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hephsla/Y,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca
Genetic Background: Not Specified

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca,Tfrctm1Nca/Tfrc+
Genetic Background: Not Specified

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

Allelic Composition: Hfetm1Sly/Hfetm1Sly
Genetic Background: Not Specified

Allelic Composition: Hfetm1Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hfetm2Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hfetm2Sly/Hfetm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hfetm3Sly/Hfetm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

Allelic Composition: Hfetm1.1Wsr/Hfetm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm1Wsr/Hfetm1Wsr,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Allelic Composition: Hfetm1Gfn/Hfetm1Gfn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm1.1Jrco/Hfetm1.1Jrco
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hfetm1.1Wsr/Hfetm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm1Wsr/Hfetm1Wsr,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hfetm1Gfn/Hfetm1Gfn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm1.1Wsr/Hfetm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hfetm1Wsr/Hfetm1Wsr,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Allelic Composition: Hfetm1Gfn/Hfetm1Gfn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008811 abnormal brain iron level "any anomaly in the amount of iron present in the brain tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hfetm2Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hfetm1.1Jrco/Hfetm1.1Jrco
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-del/Tlr4lps-del
Genetic Background: involves: C57BL/10ScN

 MP:0010161 decreased brain cholesterol level "less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hfetm2Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Hfetm2Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Hfetm2Sly/Hfetm2Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0020369 increased intestinal iron level "increase in the amount of iron present in the large or small intestinal tissue" [MGI:Anna]
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Allelic Composition: Hephsla/Hephsla,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hephsla/Y,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022797 Tfrc / Q62351 / transferrin receptor / P02786*  / reaction / complex






 

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