ENSMUSG00000007880


Mus musculus

Features
Gene ID: ENSMUSG00000007880
  
Biological name :Arid1a
  
Synonyms : A2BH40 / Arid1a / AT-rich interactive domain-containing protein 1A
  
Possible biological names infered from orthology : AT-rich interaction domain 1A / O14497
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 133679008
Gene end: 133756769
  
Corresponding Affymetrix probe sets: 10517090 (MoGene1.0st)   1417440_at (Mouse Genome 430 2.0 Array)   1448709_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008024
Ensembl peptide - ENSMUSP00000131950
Ensembl peptide - ENSMUSP00000122354
Ensembl peptide - ENSMUSP00000101517
NCBI entrez gene - 93760     See in Manteia.
MGI - MGI:1935147
RefSeq - XM_006539327
RefSeq - NM_001080819
RefSeq - XM_006539325
RefSeq - XM_006539326
RefSeq Peptide - NP_001074288
swissprot - A2BH40
swissprot - E9Q495
swissprot - E9QAQ7
Ensembl - ENSMUSG00000007880
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arid1aaENSDARG00000101710Danio rerio
 arid1abENSDARG00000101891Danio rerio
 ENSGALG00000044001Gallus gallus
 ENSGALG00000045030Gallus gallus
 ENSGALG00000043936Gallus gallus
 ENSGALG00000029316Gallus gallus
 ENSGALG00000046659Gallus gallus
 ARID1AENSG00000117713Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arid1b / E9Q4N7 / AT-rich interactive domain-containing protein 1B / Q8NFD5* / AT-rich interaction domain 1B*ENSMUSG0000006972951
Arid3b / Q9Z1N7 / AT-rich interactive domain-containing protein 3B / Q8IVW6* / AT-rich interaction domain 3B*ENSMUSG000000046616
Arid3a / Q62431 / AT-rich interactive domain-containing protein 3A / Q99856* / AT-rich interaction domain 3A*ENSMUSG000000195645
A6PWV5 / Arid3c / AT-rich interactive domain-containing protein 3C / A6NKF2* / AT-rich interaction domain 3C*ENSMUSG000000662244


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR021906  SWI/SNF-like complex subunit BAF250/Osa
 IPR030094  SWI/SNF-like complex subunit BAF250a
 IPR033388  SWI/SNF-like complex subunit BAF250, C-terminal
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001704 formation of primary germ layer IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0003205 cardiac chamber development IMP
 biological_processGO:0003408 optic cup formation involved in camera-type eye development IMP
 biological_processGO:0006325 chromatin organization IPI
 biological_processGO:0006337 nucleosome disassembly IEA
 biological_processGO:0006338 chromatin remodeling ISO
 biological_processGO:0006344 maintenance of chromatin silencing IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060674 placenta blood vessel development IMP
 biological_processGO:1901998 toxin transport IMP
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016514 SWI/SNF complex IEA
 cellular_componentGO:0070603 SWI/SNF superfamily-type complex IEA
 cellular_componentGO:0071564 npBAF complex IDA
 cellular_componentGO:0071565 nBAF complex IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016922 nuclear receptor binding IEA
 molecular_functionGO:0031491 nucleosome binding IDA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000091 short premaxilla "reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dbn1tm1.1Lbc/Dbn1+
Genetic Background: B6.Cg-Dbn1tm1.1Lbc

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor,Igs4tm1Hsas/Igs4tm1Hsas
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0001272 increased metastatic potential 
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Ednratm1Hku/Ednratm3(Ednrb)Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Ednratm1Hku/Ednratm3(Ednrb)Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0001711 abnormal placenta 
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Ednratm1Hku/Ednratm3(Ednrb)Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0002399 abnormal pluripotent precursor cell morphology/development "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednratm1Hku/Ednratm3(Ednrb)Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0002748 abnormal pulmonary valve morphology "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0003579 ovarian carcinoma 
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0004269 abnormal optic cup morphology "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005249 abnormal palatine bone morphology "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0005451 abnormal body composition "anomalous relative amounts of various components of the body, such as percent body fat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0006198 enophthalmos "sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0006354 abnormal fourth branchial arch artery morphology "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0006355 abnormal sixth branchial arch artery morphology "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0006356 abnormal third branchial arch artery morphology "any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0010565 absent fetal ductus arteriosus "absence of the fetal vessel that connects the left pulmonary artery with the descending aorta" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0010584 abnormal conotruncus septation "anomaly in the process in which the conotruncus separates into the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Arid1atm1.1Gusa/Arid1atm1.1Gusa
Genetic Background: B6.129-Arid1atm1.1Gusa

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ednratm1Hku/Ednratm3(Ednrb)Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0012098 increased spongiotrophoblast size "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Arid1am1Mag/Arid1am1Mag
Genetic Background: involves: 129 * CD-1

 MP:0012747 abnormal cardiac neural crest cell morphology "any structural anomaly of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0012752 abnormal cardiac neural crest cell migration "any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0013184 hemorrhagic ascites "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0030121 small temporal bone squamous part "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]
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Allelic Composition: Arid1atm1.1Mag/Arid1a+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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