ENSMUSG00000004661


Mus musculus

Features
Gene ID: ENSMUSG00000004661
  
Biological name :Arid3b
  
Synonyms : Arid3b / AT-rich interactive domain-containing protein 3B / Q9Z1N7
  
Possible biological names infered from orthology : AT-rich interaction domain 3B / Q8IVW6
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 57790353
Gene end: 57836793
  
Corresponding Affymetrix probe sets: 10594001 (MoGene1.0st)   1423526_at (Mouse Genome 430 2.0 Array)   1447626_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130902
Ensembl peptide - ENSMUSP00000130173
Ensembl peptide - ENSMUSP00000131677
Ensembl peptide - ENSMUSP00000004780
Ensembl peptide - ENSMUSP00000096283
Ensembl peptide - ENSMUSP00000109802
Ensembl peptide - ENSMUSP00000126889
Ensembl peptide - ENSMUSP00000127525
NCBI entrez gene - 56380     See in Manteia.
MGI - MGI:1930768
RefSeq - XM_011242776
RefSeq - NM_019689
RefSeq - XM_006511291
RefSeq - XM_006511292
RefSeq - XM_011242774
RefSeq - XM_011242775
RefSeq Peptide - NP_062663
swissprot - Q9Z1N7
swissprot - F6TCR9
swissprot - Q3V3M5
swissprot - E9Q9J9
swissprot - E9PW42
swissprot - F8WIN2
Ensembl - ENSMUSG00000004661
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arid3bENSDARG00000104034Danio rerio
 ARID3BENSGALG00000001376Gallus gallus
 ARID3BENSG00000179361Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arid3a / Q62431 / AT-rich interactive domain-containing protein 3A / Q99856* / AT-rich interaction domain 3A*ENSMUSG0000001956441
A6PWV5 / Arid3c / AT-rich interactive domain-containing protein 3C / A6NKF2* / AT-rich interaction domain 3C*ENSMUSG0000006622433
Arid1b / E9Q4N7 / AT-rich interactive domain-containing protein 1B / Q8NFD5* / AT-rich interaction domain 1B*ENSMUSG0000006972926
A2BH40 / Arid1a / AT-rich interactive domain-containing protein 1A / O14497* / AT-rich interaction domain 1A*ENSMUSG0000000788025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR023334  REKLES domain
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0011816 decreased pre-pro B cell number "reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, MGI:csmith]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0013893 decreased common lymphocyte progenitor cell number "reduced number of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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