Manteia

ENSMUSG00000019564

Mus musculus

Features

Gene ID:	ENSMUSG00000019564

Biological name :	Arid3a

Synonyms :	Arid3a / AT-rich interactive domain-containing protein 3A / Q62431

Possible biological names infered from orthology :	AT-rich interaction domain 3A / Q99856

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	C1
Gene start:	79927043
Gene end:	79955018

Corresponding Affymetrix probe sets:	10364559 (MoGene1.0st) 1419396_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000114261 Ensembl peptide - ENSMUSP00000019708 Ensembl peptide - ENSMUSP00000101015 Ensembl peptide - ENSMUSP00000101016 NCBI entrez gene - 13496 See in Manteia. MGI - MGI:1328360 RefSeq - XM_006513202 RefSeq - NM_001288625 RefSeq - NM_001288626 RefSeq - NM_007880 RefSeq - XM_006513201 RefSeq Peptide - NP_001275554 RefSeq Peptide - NP_001275555 RefSeq Peptide - NP_031906 swissprot - D3YVQ2 swissprot - Q62431 swissprot - A0A0R4J1A7 Ensembl - ENSMUSG00000019564

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
arid3a	ENSDARG00000070843	Danio rerio
ARID3A	ENSGALG00000026231	Gallus gallus
ARID3A	ENSG00000116017	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Arid3b / Q9Z1N7 / AT-rich interactive domain-containing protein 3B / Q8IVW6* / AT-rich interaction domain 3B*	ENSMUSG00000004661	39
A6PWV5 / Arid3c / AT-rich interactive domain-containing protein 3C / A6NKF2* / AT-rich interaction domain 3C*	ENSMUSG00000066224	33
Arid1b / E9Q4N7 / AT-rich interactive domain-containing protein 1B / Q8NFD5* / AT-rich interaction domain 1B*	ENSMUSG00000069729	23
A2BH40 / Arid1a / AT-rich interactive domain-containing protein 1A / O14497* / AT-rich interaction domain 1A*	ENSMUSG00000007880	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR001606	ARID DNA-binding domain
IPR023334	REKLES domain
IPR036431	ARID DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IDA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0043231	intracellular membrane-bounded organelle	ISO
cellular_component	GO:0045121	membrane raft	ISO
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IMP
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0042803	protein homodimerization activity	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0000600	liver hypoplasia	"reduced size of liver due to decreased cell number " [J:57631]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0001711	abnormal placenta		Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0001722	pale yolk sac	"bloodless yolk sac" [J:62571]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0003795	abnormal bone structure		Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0004057	thin myocardial compact layer	"reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0004229	abnormal embryonic erythropoiesis	"anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0004808	abnormal hematopoietic stem cell morphology	"any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0004816	abnormal class switch recombination	"anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0004978	decreased B-1 B cell number	"reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0005561	increased mean corpuscular hemoglobin	"greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0005650	abnormal limb bud morphology	"aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0008168	decreased B-1a cell number	"reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008182	decreased marginal zone B cell number	"reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008190	decreased transitional stage B cell number	"reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008207	decreased B-2 cell number	"reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008249	abnormal common lymphocyte progenitor cell morphology	"any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008813	decreased common myeloid progenitor cell number	"reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0009923	decreased transitional stage T1 B cell number	"reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0009926	decreased transitional stage T2 B cell number	"reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0010831	partial lethality	"the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics
MP:0013294	prenatal lethality prior to heart atrial septation	"death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]	Show Allelic Composition: App^{tm1b(KOMP)Wtsi}/App⁺ Genetic Background: C57BL/6N-App^{tm1b(KOMP)Wtsi}/Ics

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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