ENSMUSG00000010064


Mus musculus

Features
Gene ID: ENSMUSG00000010064
  
Biological name :Slc38a3
  
Synonyms : Q9DCP2 / Slc38a3 / Sodium-coupled neutral amino acid transporter 3
  
Possible biological names infered from orthology : Q99624 / solute carrier family 38 member 3
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 107650634
Gene end: 107669530
  
Corresponding Affymetrix probe sets: 10596718 (MoGene1.0st)   1418706_at (Mouse Genome 430 2.0 Array)   1446013_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141484
Ensembl peptide - ENSMUSP00000142087
Ensembl peptide - ENSMUSP00000141850
Ensembl peptide - ENSMUSP00000141569
Ensembl peptide - ENSMUSP00000141552
Ensembl peptide - ENSMUSP00000141528
Ensembl peptide - ENSMUSP00000010208
Ensembl peptide - ENSMUSP00000130414
Ensembl peptide - ENSMUSP00000137561
NCBI entrez gene - 76257     See in Manteia.
MGI - MGI:1923507
RefSeq - XM_017313682
RefSeq - NM_001199217
RefSeq - NM_001199218
RefSeq - NM_023805
RefSeq Peptide - NP_076294
RefSeq Peptide - NP_001186146
RefSeq Peptide - NP_001186147
swissprot - A0A0A6YWH4
swissprot - A0A0A6YWF5
swissprot - A0A0A6YWI8
swissprot - A0A0A6YWC0
swissprot - Q9DCP2
swissprot - A0A0A6YX60
Ensembl - ENSMUSG00000010064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc38a3aENSDARG00000027065Danio rerio
 slc38a3bENSDARG00000091061Danio rerio
 SLC38A3ENSGALG00000028871Gallus gallus
 Q99624ENSG00000188338Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3U1J0 / Slc38a5 / Sodium-coupled neutral amino acid transporter 5 / Q8WUX1* / solute carrier family 38 member 5*ENSMUSG0000003117056
Q8R1S9 / Slc38a4 / Mus musculus solute carrier family 38, member 4 (Slc38a4), transcript variant 1, mRNA. / Q969I6* / solute carrier family 38 member 4*ENSMUSG0000002246453
Q8CFE6 / Slc38a2 / Sodium-coupled neutral amino acid transporter 2 / Q96QD8* / solute carrier family 38 member 2*ENSMUSG0000002246251
Q8K2P7 / Slc38a1 / Sodium-coupled neutral amino acid transporter 1 / Q9H2H9* / solute carrier family 38 member 1*ENSMUSG0000002316947
G3UVW3 / Slc38a6 / Probable sodium-coupled neutral amino acid transporter 6 / Q8IZM9* / solute carrier family 38 member 6*ENSMUSG0000004471241
Q3USY0 / Slc38a11 / Putative sodium-coupled neutral amino acid transporter 11 / Q08AI6* / solute carrier family 38 member 11*ENSMUSG0000006117123
Q5I012 / Slc38a10 / Putative sodium-coupled neutral amino acid transporter 10 / Q9HBR0* / solute carrier family 38 member 10*ENSMUSG0000006130619


Protein motifs (from Interpro)
Interpro ID Name
 IPR013057  Amino acid transporter, transmembrane domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0006867 asparagine transport ISO
 biological_processGO:0006868 glutamine transport ISO
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0015808 L-alanine transport ISO
 biological_processGO:0015817 histidine transport ISO
 biological_processGO:0051365 cellular response to potassium ion starvation IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH IDA
 biological_processGO:0089709 L-histidine transmembrane transport IEA
 biological_processGO:2000487 positive regulation of glutamine transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0005290 L-histidine transmembrane transporter activity ISO
 molecular_functionGO:0015180 L-alanine transmembrane transporter activity ISO
 molecular_functionGO:0015182 L-asparagine transmembrane transporter activity ISO
 molecular_functionGO:0015186 L-glutamine transmembrane transporter activity ISO
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015297 antiporter activity IEA


Pathways (from Reactome)
Pathway description
Amino acid transport across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0003979 increased circulating carnitine level "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0011652 increased circulating histidine level "the amount of the amino acid histidine in the blood is more than expected" [MGI:llw2]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0011736 decreased urine ammonia level "a reduced amount of ammonia in the urine compared to the normal state" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0012335 increased circulating homocysteine level "greater amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0013724 decreased circulating tyrosine level "the amount of the amino acid histidine in the blood is less than expected" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr