ENSMUSG00000022094


Mus musculus

Features
Gene ID: ENSMUSG00000022094
  
Biological name :Slc39a14
  
Synonyms : Q75N73 / Slc39a14 / solute carrier family 39 (zinc transporter), member 14
  
Possible biological names infered from orthology : Q15043 / solute carrier family 39 member 14
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 70303469
Gene end: 70351425
  
Corresponding Affymetrix probe sets: 10421309 (MoGene1.0st)   1425649_at (Mouse Genome 430 2.0 Array)   1427035_at (Mouse Genome 430 2.0 Array)   1438490_at (Mouse Genome 430 2.0 Array)   1457770_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066108
Ensembl peptide - ENSMUSP00000122816
Ensembl peptide - ENSMUSP00000122615
Ensembl peptide - ENSMUSP00000119040
Ensembl peptide - ENSMUSP00000118319
Ensembl peptide - ENSMUSP00000117792
Ensembl peptide - ENSMUSP00000117010
Ensembl peptide - ENSMUSP00000022688
NCBI entrez gene - 213053     See in Manteia.
MGI - MGI:2384851
RefSeq - XM_006518791
RefSeq - NM_001135151
RefSeq - NM_001135152
RefSeq - NM_144808
RefSeq - XM_006518786
RefSeq - XM_006518787
RefSeq - XM_006518788
RefSeq - XM_006518789
RefSeq Peptide - NP_001128623
RefSeq Peptide - NP_659057
RefSeq Peptide - NP_001128624
swissprot - D3YXD7
swissprot - A0A0R4J1V1
swissprot - D3Z4Q7
swissprot - D3Z6P5
swissprot - Q75N73
swissprot - D3Z3C5
swissprot - D3Z354
Ensembl - ENSMUSG00000022094
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc39a14ENSDARG00000102387Danio rerio
 Q15043ENSG00000104635Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91W10 / Slc39a8 / Zinc transporter ZIP8 / Q9C0K1* / solute carrier family 39 member 8*ENSMUSG0000005389748
Q6P5F6 / Slc39a10 / Zinc transporter ZIP10 / Q9ULF5* / solute carrier family 39 member 10*ENSMUSG0000002598633
Q8C145 / Slc39a6 / Zinc transporter ZIP6 / Q13433* / solute carrier family 39 member 6*ENSMUSG0000002427031
Q5FWH7 / Slc39a12 / Zinc transporter ZIP12 / Q504Y0* / solute carrier family 39 member 12*ENSMUSG0000003694929
Q78IQ7 / Slc39a4 / solute carrier family 39 (zinc transporter), member 4 / Q6P5W5* / solute carrier family 39 member 4*ENSMUSG0000006335427
Q9D856 / Slc39a5 / Zinc transporter ZIP5 / Q6ZMH5* / solute carrier family 39 member 5*ENSMUSG0000003987823
Q31125 / Slc39a7 / solute carrier family 39 (zinc transporter), member 7 / Q92504* / solute carrier family 39 member 7*ENSMUSG0000002432720
Q8BZH0 / Slc39a13 / solute carrier family 39 (metal ion transporter), member 13 / Q96H72* / solute carrier family 39 member 13*ENSMUSG0000000210517


Protein motifs (from Interpro)
Interpro ID Name
 IPR003689  Zinc/iron permease


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006826 iron ion transport IDA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0006882 cellular zinc ion homeostasis IEA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071421 manganese ion transmembrane transport IEA
 biological_processGO:0071577 zinc ion transmembrane transport IEA
 biological_processGO:0071578 zinc ion import across plasma membrane IEA
 biological_processGO:1903874 ferrous iron transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005384 manganese ion transmembrane transporter activity ISS
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IEA
 molecular_functionGO:0015093 ferrous iron transmembrane transporter activity IDA
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Zinc influx into cells by the SLC39 gene family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0003968 abnormal growth hormone level 
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0011924 abnormal liver zinc level "anomaly in the amount of zinc present in the liver tissue" [MPD:Molly]
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Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Slc39a14tm1Lex/Slc39a14tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0030126 torticollis "involuntary contractions of the neck musculature resulting in an abnormal posture of or abnormal movements of the head" [HP:0000473]
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Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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