ENSMUSG00000025986


Mus musculus

Features
Gene ID: ENSMUSG00000025986
  
Biological name :Slc39a10
  
Synonyms : Q6P5F6 / Slc39a10 / Zinc transporter ZIP10
  
Possible biological names infered from orthology : Q9ULF5 / solute carrier family 39 member 10
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C1.1
Gene start: 46807544
Gene end: 46892852
  
Corresponding Affymetrix probe sets: 10354389 (MoGene1.0st)   1433751_at (Mouse Genome 430 2.0 Array)   1439041_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140570
Ensembl peptide - ENSMUSP00000027131
Ensembl peptide - ENSMUSP00000140176
NCBI entrez gene - 227059     See in Manteia.
MGI - MGI:1914515
RefSeq - XM_006495935
RefSeq - NM_172653
RefSeq - XM_006495932
RefSeq - XM_006495933
RefSeq - XM_006495934
RefSeq Peptide - NP_766241
RefSeq Peptide - NP_001343345
RefSeq Peptide - NP_001343346
swissprot - Q6P5F6
swissprot - A0A087WRC8
swissprot - A0A087WQF7
Ensembl - ENSMUSG00000025986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc39a10ENSDARG00000005823Danio rerio
 SLC39A10ENSGALG00000007777Gallus gallus
 Q9ULF5ENSG00000196950Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C145 / Slc39a6 / Zinc transporter ZIP6 / Q13433* / solute carrier family 39 member 6*ENSMUSG0000002427035
Q9D856 / Slc39a5 / Zinc transporter ZIP5 / Q6ZMH5* / solute carrier family 39 member 5*ENSMUSG0000003987822
Q5FWH7 / Slc39a12 / Zinc transporter ZIP12 / Q504Y0* / solute carrier family 39 member 12*ENSMUSG0000003694921
Q75N73 / Slc39a14 / solute carrier family 39 (zinc transporter), member 14 / Q15043* / solute carrier family 39 member 14*ENSMUSG0000002209419
Q78IQ7 / Slc39a4 / solute carrier family 39 (zinc transporter), member 4 / Q6P5W5* / solute carrier family 39 member 4*ENSMUSG0000006335419
Q91W10 / Slc39a8 / Zinc transporter ZIP8 / Q9C0K1* / solute carrier family 39 member 8*ENSMUSG0000005389718
Q31125 / Slc39a7 / solute carrier family 39 (zinc transporter), member 7 / Q92504* / solute carrier family 39 member 7*ENSMUSG0000002432715
Q8BZH0 / Slc39a13 / solute carrier family 39 (metal ion transporter), member 13 / Q96H72* / solute carrier family 39 member 13*ENSMUSG000000021059


Protein motifs (from Interpro)
Interpro ID Name
 IPR003689  Zinc/iron permease


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002903 negative regulation of B cell apoptotic process IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0006882 cellular zinc ion homeostasis IMP
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071578 zinc ion import across plasma membrane IMP
 biological_processGO:1903615 positive regulation of protein tyrosine phosphatase activity IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IMP
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0003941 abnormal skin development "anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0009598 thin epidermis stratum granulosum "decreased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0011687 decreased epidermal stem cell number "a reduction in the number of somatic stem cells that are part of the epidermis" [CL:1000428, MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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