ENSMUSG00000053897


Mus musculus

Features
Gene ID: ENSMUSG00000053897
  
Biological name :Slc39a8
  
Synonyms : Q91W10 / Slc39a8 / Zinc transporter ZIP8
  
Possible biological names infered from orthology : Q9C0K1 / solute carrier family 39 member 8
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 135825279
Gene end: 135888572
  
Corresponding Affymetrix probe sets: 10496324 (MoGene1.0st)   1416832_at (Mouse Genome 430 2.0 Array)   1448482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029810
Ensembl peptide - ENSMUSP00000080640
Ensembl peptide - ENSMUSP00000128245
Ensembl peptide - ENSMUSP00000136634
NCBI entrez gene - 67547     See in Manteia.
MGI - MGI:1914797
RefSeq - XM_006501934
RefSeq - NM_001135149
RefSeq - NM_001135150
RefSeq - NM_026228
RefSeq Peptide - NP_001128622
RefSeq Peptide - NP_080504
RefSeq Peptide - NP_001128621
swissprot - Q91W10
Ensembl - ENSMUSG00000053897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018202.1ENSDARG00000113547Danio rerio
 slc39a8ENSDARG00000056757Danio rerio
 SLC39A8ENSGALG00000012298Gallus gallus
 Q9C0K1ENSG00000138821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q75N73 / Slc39a14 / solute carrier family 39 (zinc transporter), member 14 / Q15043* / solute carrier family 39 member 14*ENSMUSG0000002209451
Q6P5F6 / Slc39a10 / Zinc transporter ZIP10 / Q9ULF5* / solute carrier family 39 member 10*ENSMUSG0000002598632
Q8C145 / Slc39a6 / Zinc transporter ZIP6 / Q13433* / solute carrier family 39 member 6*ENSMUSG0000002427030
Q78IQ7 / Slc39a4 / solute carrier family 39 (zinc transporter), member 4 / Q6P5W5* / solute carrier family 39 member 4*ENSMUSG0000006335427
Q5FWH7 / Slc39a12 / Zinc transporter ZIP12 / Q504Y0* / solute carrier family 39 member 12*ENSMUSG0000003694926
Q9D856 / Slc39a5 / Zinc transporter ZIP5 / Q6ZMH5* / solute carrier family 39 member 5*ENSMUSG0000003987826
Q31125 / Slc39a7 / solute carrier family 39 (zinc transporter), member 7 / Q92504* / solute carrier family 39 member 7*ENSMUSG0000002432719
Q8BZH0 / Slc39a13 / solute carrier family 39 (metal ion transporter), member 13 / Q96H72* / solute carrier family 39 member 13*ENSMUSG0000000210516


Protein motifs (from Interpro)
Interpro ID Name
 IPR003689  Zinc/iron permease


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006829 zinc ion transport ISS
 biological_processGO:0006882 cellular zinc ion homeostasis IBA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070574 cadmium ion transmembrane transport IDA
 biological_processGO:0071578 zinc ion import across plasma membrane IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane ISO
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IBA
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Zinc influx into cells by the SLC39 gene family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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