ENSMUSG00000063354


Mus musculus

Features
Gene ID: ENSMUSG00000063354
  
Biological name :Slc39a4
  
Synonyms : Q78IQ7 / Slc39a4 / solute carrier family 39 (zinc transporter), member 4
  
Possible biological names infered from orthology : Q6P5W5 / solute carrier family 39 member 4
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76612383
Gene end: 76617384
  
Corresponding Affymetrix probe sets: 10430006 (MoGene1.0st)   1451139_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073134
Ensembl peptide - ENSMUSP00000155442
NCBI entrez gene - 72027     See in Manteia.
MGI - MGI:1919277
RefSeq - XM_006521427
RefSeq - NM_028064
RefSeq Peptide - NP_082340
swissprot - Q78IQ7
Ensembl - ENSMUSG00000063354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc39a4ENSDARG00000059361Danio rerio
 Q6P5W5ENSG00000147804Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5FWH7 / Slc39a12 / Zinc transporter ZIP12 / Q504Y0* / solute carrier family 39 member 12*ENSMUSG0000003694931
Q6P5F6 / Slc39a10 / Zinc transporter ZIP10 / Q9ULF5* / solute carrier family 39 member 10*ENSMUSG0000002598625
Q9D856 / Slc39a5 / Zinc transporter ZIP5 / Q6ZMH5* / solute carrier family 39 member 5*ENSMUSG0000003987823
Q8C145 / Slc39a6 / Zinc transporter ZIP6 / Q13433* / solute carrier family 39 member 6*ENSMUSG0000002427023
Q75N73 / Slc39a14 / solute carrier family 39 (zinc transporter), member 14 / Q15043* / solute carrier family 39 member 14*ENSMUSG0000002209420
Q91W10 / Slc39a8 / Zinc transporter ZIP8 / Q9C0K1* / solute carrier family 39 member 8*ENSMUSG0000005389719
Q31125 / Slc39a7 / solute carrier family 39 (zinc transporter), member 7 / Q92504* / solute carrier family 39 member 7*ENSMUSG0000002432718
Q8BZH0 / Slc39a13 / solute carrier family 39 (metal ion transporter), member 13 / Q96H72* / solute carrier family 39 member 13*ENSMUSG0000000210515


Protein motifs (from Interpro)
Interpro ID Name
 IPR003689  Zinc/iron permease


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0006882 cellular zinc ion homeostasis IDA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0034224 cellular response to zinc ion starvation IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071578 zinc ion import across plasma membrane IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IDA
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Zinc influx into cells by the SLC39 gene family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0003066 increased hepatic copper content "a greater accumulation of copper in the liver tissue compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0003067 decreased hepatic copper content "a reduced amount of copper in the liver tissue compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003952 abnormal copper level "anomaly in the concentration in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005636 abnormal mineral homeostasis "anomaly in the state of equilibrium in the body with respect to any of the inorganic substance that have importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0009615 abnormal zinc homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of zinc that normally is a cofactor in many proteins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0010248 decreased intestine copper level "a reduced amount of copper in the intestinal tissue compared to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020385 decreased intestinal iron level "reduction in the amount of iron present in the large or small intestinal tissue" [MGI:Anna]
Show

Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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