ENSMUSG00000024837


Mus musculus

Features
Gene ID: ENSMUSG00000024837
  
Biological name :Dmrt1
  
Synonyms : Dmrt1 / Doublesex- and mab-3-related transcription factor 1 / Q9QZ59
  
Possible biological names infered from orthology : Q9Y5R6
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: B
Gene start: 25505618
Gene end: 25604329
  
Corresponding Affymetrix probe sets: 10462217 (MoGene1.0st)   1423582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025755
Ensembl peptide - ENSMUSP00000084803
NCBI entrez gene - 50796     See in Manteia.
MGI - MGI:1354733
RefSeq - XM_011247280
RefSeq - NM_015826
RefSeq Peptide - NP_056641
swissprot - Q9QZ59
Ensembl - ENSMUSG00000024837
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dmrt1ENSDARG00000007349Danio rerio
 DMRT1ENSGALG00000010160Gallus gallus
 DMRT1ENSG00000137090Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2A9A2 / Dmrta2 / Doublesex- and mab-3-related transcription factor A2 / Q96SC8* / DMRT like family A2*ENSMUSG0000004714324
Dmrt2 / Q8BG36 / Doublesex- and mab-3-related transcription factor 2 / Q9Y5R5*ENSMUSG0000004813824
Dmrta1 / Q8CFG4 / Doublesex- and mab-3-related transcription factor A1 / Q5VZB9* / DMRT like family A1*ENSMUSG0000004375322
Dmrt3 / Q80WT2 / Doublesex- and mab-3-related transcription factor 3 / Q9NQL9*ENSMUSG0000004237220
A2A9I7 / Dmrtb1 / Doublesex- and mab-3-related transcription factor B1 / Q96MA1* / DMRT like family B with proline rich C-terminal 1*ENSMUSG0000002861018
Dmrtc2 / Q8CGW9 / Doublesex- and mab-3-related transcription factor C2 / Q8IXT2* / DMRT like family C2*ENSMUSG0000001134917
Dmrtc1b / DMRTC1* / Q5HYR2* / DMRT like family C1* / DMRT like family C1B*ENSMUSG000000730279
Q9D9R7 / Dmrtc1a / Doublesex- and mab-3-related transcription factor C1 / DMRTC1* / Q5HYR2* / DMRTC1B* / DMRT like family C1* / DMRT like family C1B*ENSMUSG000000313236


Protein motifs (from Interpro)
Interpro ID Name
 IPR001275  DM DNA-binding domain
 IPR022114  Doublesex- and mab-3-related transcription factor 1-like
 IPR026607  DMRT/protein doublesex/protein male abnormal 3
 IPR036407  DM DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0002176 male germ cell proliferation IMP
 biological_processGO:0003006 developmental process involved in reproduction IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007548 sex differentiation IEA
 biological_processGO:0008354 germ cell migration IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030238 male sex determination IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045835 negative regulation of meiotic nuclear division IMP
 biological_processGO:0045840 positive regulation of mitotic nuclear division IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046661 male sex differentiation IMP
 biological_processGO:0048599 oocyte development IMP
 biological_processGO:0060008 Sertoli cell differentiation IMP
 biological_processGO:0060009 Sertoli cell development IMP
 biological_processGO:0060903 positive regulation of meiosis I IMP
 biological_processGO:1900107 regulation of nodal signaling pathway IMP
 biological_processGO:2000020 positive regulation of male gonad development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm9Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm9Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm9Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002776 Sertoli cell hyperplasia "increased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:71710, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm9Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm9Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
Show

Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm9Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dmrt1tm1Zark/Dmrt1tm1.1Zark,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dmrt1tm1Zark/Dmrt1tm1.1Zark
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004109 abnormal Sertoli cell development "anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmrt1tm1Zark/Dmrt1tm1.1Zark,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm9Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dmrt1tm1Zark/Dmrt1tm1.1Zark
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm9Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmrt1tm1Zark/Dmrt1tm1.1Zark,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dmrt1tm1Zark/Dmrt1tm1.1Zark
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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