Manteia

ENSMUSG00000047143

Mus musculus

Features

Gene ID:	ENSMUSG00000047143

Biological name :	Dmrta2

Synonyms :	A2A9A2 / Dmrta2 / Doublesex- and mab-3-related transcription factor A2

Possible biological names infered from orthology :	DMRT like family A2 / Q96SC8

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	C7
Gene start:	109978053
Gene end:	109983687

Corresponding Affymetrix probe sets:	10507011 (MoGene1.0st) 1441107_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000060441 NCBI entrez gene - 242620 See in Manteia. MGI - MGI:2653629 RefSeq - XM_006503094 RefSeq - NM_172296 RefSeq - XM_006503093 RefSeq Peptide - NP_758500 swissprot - A2A9A2 Ensembl - ENSMUSG00000047143

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dmrta2	ENSDARG00000039412	Danio rerio
DMRTA2	ENSGALG00000031423	Gallus gallus
DMRTA2	ENSG00000142700	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dmrta1 / Q8CFG4 / Doublesex- and mab-3-related transcription factor A1 / Q5VZB9* / DMRT like family A1*	ENSMUSG00000043753	33
Dmrt3 / Q80WT2 / Doublesex- and mab-3-related transcription factor 3 / Q9NQL9*	ENSMUSG00000042372	27
Dmrt2 / Q8BG36 / Doublesex- and mab-3-related transcription factor 2 / Q9Y5R5*	ENSMUSG00000048138	21
Dmrt1 / Q9QZ59 / Doublesex- and mab-3-related transcription factor 1 / Q9Y5R6*	ENSMUSG00000024837	17
Dmrtc2 / Q8CGW9 / Doublesex- and mab-3-related transcription factor C2 / Q8IXT2* / DMRT like family C2*	ENSMUSG00000011349	15
A2A9I7 / Dmrtb1 / Doublesex- and mab-3-related transcription factor B1 / Q96MA1* / DMRT like family B with proline rich C-terminal 1*	ENSMUSG00000028610	13
Dmrtc1b / DMRTC1* / Q5HYR2* / DMRT like family C1* / DMRT like family C1B*	ENSMUSG00000073027	5
Q9D9R7 / Dmrtc1a / Doublesex- and mab-3-related transcription factor C1 / DMRTC1* / Q5HYR2* / DMRTC1B* / DMRT like family C1* / DMRT like family C1B*	ENSMUSG00000031323	5

Protein motifs (from Interpro)

Interpro ID	Name
IPR001275	DM DNA-binding domain
IPR005173	DMRTA motif
IPR009060	UBA-like superfamily
IPR026607	DMRT/protein doublesex/protein male abnormal 3
IPR036407	DM DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002052	positive regulation of neuroblast proliferation	IMP
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0021796	cerebral cortex regionalization	IMP
biological_process	GO:0035914	skeletal muscle cell differentiation	IMP
biological_process	GO:0048665	neuron fate specification	IMP
biological_process	GO:0071542	dopaminergic neuron differentiation	IMP
cellular_component	GO:0005634	nucleus	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IDA
molecular_function	GO:0043565	sequence-specific DNA binding	IDA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000778	abnormal tract		Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000785	telencephalon hypoplasia	"reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Mut^tm1Cpv/Mut^tm1Cpv,Tg(Alb-Mut)#Cpv/0 Genetic Background: involves: C57BL/6 Allelic Composition: Dmrta2^tm1.2Fuma/Dmrta2^tm1.2Fuma Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N * SJL
MP:0000787	abnormal telencephalon morphology	"any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Mut^tm1Cpv/Mut^tm1Cpv,Tg(Alb-Mut)#Cpv/0 Genetic Background: involves: C57BL/6 Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0000789	thickened cerebral cortex	"Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0000809	absent hippocampus	"missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]	Show Allelic Composition: Dmrta2^tm1.2Fuma/Dmrta2^tm1.2Fuma Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N * SJL Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0000814	absent dentate gyrus	"lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002199	abnormal brain commissure morphology	"absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Dmrta2^tm1.2Fuma/Dmrta2^tm1.2Fuma Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N * SJL Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dmrta2^tm1.2Fuma/Dmrta2^tm1.2Fuma Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N * SJL Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0004981	decreased neuronal precursor cell number	"reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dmrta2^tm1.2Fuma/Dmrta2^tm1.2Fuma Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N * SJL
MP:0006254	thin cerebral cortex	"decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0008031	decreased Cajal-Retzius cell number	"reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0008440	abnormal subplate morphology	"any strucutral anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0008458	abnormal cortical ventricular zone morphology	"any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0008540	abnormal cerebrum morphology	"any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0008547	abnormal neocortex morphology	"any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0008934	absent choroid plexus	"absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0008948	decreased neuron number	"fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Dmrta2^tm1.2Fuma/Dmrta2^tm1.2Fuma Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N * SJL
MP:0009546	absent gastric milk in neonates	"failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd Genetic Background: involves: C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr