ENSMUSG00000011349


Mus musculus

Features
Gene ID: ENSMUSG00000011349
  
Biological name :Dmrtc2
  
Synonyms : Dmrtc2 / Doublesex- and mab-3-related transcription factor C2 / Q8CGW9
  
Possible biological names infered from orthology : DMRT like family C2 / Q8IXT2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 24870057
Gene end: 24877651
  
Corresponding Affymetrix probe sets: 10551011 (MoGene1.0st)   1453872_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000011493
NCBI entrez gene - 71241     See in Manteia.
MGI - MGI:1918491
RefSeq - XM_017312307
RefSeq - NM_027732
RefSeq - XM_006540358
RefSeq - XM_006540359
RefSeq Peptide - NP_082008
swissprot - Q8CGW9
Ensembl - ENSMUSG00000011349
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dmrt2bENSDARG00000070013Danio rerio
 DMRTC2ENSG00000142025Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dmrt3 / Q80WT2 / Doublesex- and mab-3-related transcription factor 3 / Q9NQL9*ENSMUSG0000004237222
A2A9A2 / Dmrta2 / Doublesex- and mab-3-related transcription factor A2 / Q96SC8* / DMRT like family A2*ENSMUSG0000004714322
Dmrtc1b / DMRTC1* / Q5HYR2* / DMRT like family C1* / DMRT like family C1B*ENSMUSG0000007302721
Dmrt2 / Q8BG36 / Doublesex- and mab-3-related transcription factor 2 / Q9Y5R5*ENSMUSG0000004813821
Dmrta1 / Q8CFG4 / Doublesex- and mab-3-related transcription factor A1 / Q5VZB9* / DMRT like family A1*ENSMUSG0000004375319
Q9D9R7 / Dmrtc1a / Doublesex- and mab-3-related transcription factor C1 / DMRTC1* / Q5HYR2* / DMRTC1B* / DMRT like family C1* / DMRT like family C1B*ENSMUSG0000003132319
A2A9I7 / Dmrtb1 / Doublesex- and mab-3-related transcription factor B1 / Q96MA1* / DMRT like family B with proline rich C-terminal 1*ENSMUSG0000002861018
Dmrt1 / Q9QZ59 / Doublesex- and mab-3-related transcription factor 1 / Q9Y5R6*ENSMUSG0000002483717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001275  DM DNA-binding domain
 IPR026607  DMRT/protein doublesex/protein male abnormal 3
 IPR031577  Doublesex- and mab-3-related transcription factor C1/C2, C-terminal
 IPR036407  DM DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007290 spermatid nucleus elongation IMP
 biological_processGO:0007548 sex differentiation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:1900111 positive regulation of histone H3-K9 dimethylation IMP
 biological_processGO:1900114 positive regulation of histone H3-K9 trimethylation IMP
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Sall4tm2Ryn/Sall4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dmrtc2tm1.1Zark/Dmrtc2tm1.1Zark,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Sall4tm2Ryn/Sall4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sall4tm2Ryn/Sall4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sall4tm2Ryn/Sall4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-23J/Kitl+
Genetic Background: B6Smn(C3)-KitlSl-23J/J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm2Ryn/Sall4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dmrtc2tm1.2Zark/Dmrtc2tm1.2Zark
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sall4tm2Ryn/Sall4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dmrtc2tm1.2Zark/Dmrtc2tm1.2Zark
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmrtc2tm1.2Zark/Dmrtc2tm1.2Zark
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr