ENSMUSG00000042372


Mus musculus

Features
Gene ID: ENSMUSG00000042372
  
Biological name :Dmrt3
  
Synonyms : Dmrt3 / Doublesex- and mab-3-related transcription factor 3 / Q80WT2
  
Possible biological names infered from orthology : Q9NQL9
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: B
Gene start: 25610537
Gene end: 25623920
  
Corresponding Affymetrix probe sets: 10462228 (MoGene1.0st)   1420182_x_at (Mouse Genome 430 2.0 Array)   1440707_at (Mouse Genome 430 2.0 Array)   1449763_at (Mouse Genome 430 2.0 Array)   1460267_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046812
NCBI entrez gene - 240590     See in Manteia.
MGI - MGI:2449470
RefSeq - NM_177360
RefSeq - XM_006527066
RefSeq Peptide - NP_796334
swissprot - Q80WT2
Ensembl - ENSMUSG00000042372
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dmrt3aENSDARG00000035290Danio rerio
 DMRT3ENSGALG00000010161Gallus gallus
 DMRT3ENSG00000064218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2A9A2 / Dmrta2 / Doublesex- and mab-3-related transcription factor A2 / Q96SC8* / DMRT like family A2*ENSMUSG0000004714330
Dmrta1 / Q8CFG4 / Doublesex- and mab-3-related transcription factor A1 / Q5VZB9* / DMRT like family A1*ENSMUSG0000004375324
Dmrt2 / Q8BG36 / Doublesex- and mab-3-related transcription factor 2 / Q9Y5R5*ENSMUSG0000004813822
Dmrtc2 / Q8CGW9 / Doublesex- and mab-3-related transcription factor C2 / Q8IXT2* / DMRT like family C2*ENSMUSG0000001134917
Dmrt1 / Q9QZ59 / Doublesex- and mab-3-related transcription factor 1 / Q9Y5R6*ENSMUSG0000002483716
A2A9I7 / Dmrtb1 / Doublesex- and mab-3-related transcription factor B1 / Q96MA1* / DMRT like family B with proline rich C-terminal 1*ENSMUSG0000002861014
Dmrtc1b / DMRTC1* / Q5HYR2* / DMRT like family C1* / DMRT like family C1B*ENSMUSG000000730277
Q9D9R7 / Dmrtc1a / Doublesex- and mab-3-related transcription factor C1 / DMRTC1* / Q5HYR2* / DMRTC1B* / DMRT like family C1* / DMRT like family C1B*ENSMUSG000000313234


Protein motifs (from Interpro)
Interpro ID Name
 IPR001275  DM DNA-binding domain
 IPR005173  DMRTA motif
 IPR009060  UBA-like superfamily
 IPR026607  DMRT/protein doublesex/protein male abnormal 3
 IPR036407  DM DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007548 sex differentiation IEA
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0019226 transmission of nerve impulse IMP
 biological_processGO:0021521 ventral spinal cord interneuron specification IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IMP
 biological_processGO:0046661 male sex differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003880 abnormal central pattern generator function "anomalous function of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:101019]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Dmrta2tm1.2Fuma/Dmrta2tm1.2Fuma
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N * SJL

 MP:0010540 long stride length "increased average distance between steps" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr