ENSMUSG00000025203


Mus musculus

Features
Gene ID: ENSMUSG00000025203
  
Biological name :Scd2
  
Synonyms : P13011 / Scd2 / stearoyl-Coenzyme A desaturase 2
  
Possible biological names infered from orthology : O00767 / SCD / stearoyl-CoA desaturase
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 44293676
Gene end: 44306864
  
Corresponding Affymetrix probe sets: 10463355 (MoGene1.0st)   1415822_at (Mouse Genome 430 2.0 Array)   1415823_at (Mouse Genome 430 2.0 Array)   1415824_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026221
NCBI entrez gene - 20250     See in Manteia.
MGI - MGI:98240
RefSeq - NM_009128
RefSeq Peptide - NP_033154
swissprot - P13011
Ensembl - ENSMUSG00000025203
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scdENSDARG00000033662Danio rerio
 scdbENSDARG00000030265Danio rerio
 SCDENSGALG00000005739Gallus gallus
 SCDENSG00000099194Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scd1 / P13516 / stearoyl-Coenzyme A desaturase 1 / SCD* / O00767* / stearoyl-CoA desaturase*ENSMUSG0000003707187
Scd3 / Q99PL7 / Acyl-CoA desaturase 3 / SCD* / O00767* / stearoyl-CoA desaturase*ENSMUSG0000002520285
Scd4 / Q6T707 / Acyl-CoA desaturase 4 / SCD* / O00767* / stearoyl-CoA desaturase*ENSMUSG0000005019578


Protein motifs (from Interpro)
Interpro ID Name
 IPR001522  Fatty acid desaturase type 1, conserved site
 IPR005804  Fatty acid desaturase domain
 IPR015876  Acyl-CoA desaturase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1903966 monounsaturated fatty acid biosynthetic process IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004768 stearoyl-CoA 9-desaturase activity IGI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
 molecular_functionGO:0032896 palmitoyl-CoA 9-desaturase activity IGI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0003849 greasy coat "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0009608 abnormal lamellar body morphology "any structural anomaly of a membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae" [GO:0042599]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0009794 sebaceous gland hyperplasia "overdevelopment and increased size of the sebum secreting glands of the hair shaft, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025202 Scd3 / Q99PL7 / Acyl-CoA desaturase 3 / SCD* / O00767* / stearoyl-CoA desaturase*  / complex
 ENSMUSG00000050195 Scd4 / Q6T707 / Acyl-CoA desaturase 4 / SCD* / O00767* / stearoyl-CoA desaturase*  / complex
 ENSMUSG00000037071 Scd1 / P13516 / stearoyl-Coenzyme A desaturase 1 / SCD* / O00767* / stearoyl-CoA desaturase*  / complex
 ENSMUSG00000025203 Scd2 / P13011 / stearoyl-Coenzyme A desaturase 2 / SCD* / O00767* / stearoyl-CoA desaturase*  / complex






 

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