Manteia - Molecule gene

ENSMUSG00000037071

Mus musculus

Features

Gene ID:	ENSMUSG00000037071

Biological name :	Scd1

Synonyms :	P13516 / Scd1 / stearoyl-Coenzyme A desaturase 1

Possible biological names infered from orthology :	O00767 / SCD / stearoyl-CoA desaturase

Species:	Mus musculus

Chr. number:	19
Strand:	-1
Band:	C3
Gene start:	44394451
Gene end:	44407709

Corresponding Affymetrix probe sets:	10467979 (MoGene1.0st) 1415964_at (Mouse Genome 430 2.0 Array) 1415965_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000036936 NCBI entrez gene - 20249 See in Manteia. MGI - MGI:98239 RefSeq - NM_009127 RefSeq Peptide - NP_033153 swissprot - P13516 swissprot - Q547C4 Ensembl - ENSMUSG00000037071

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
scd	ENSDARG00000033662	Danio rerio
scdb	ENSDARG00000030265	Danio rerio
SCD	ENSGALG00000005739	Gallus gallus
SCD	ENSG00000099194	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Scd3 / Q99PL7 / Acyl-CoA desaturase 3 / SCD* / O00767* / stearoyl-CoA desaturase*	ENSMUSG00000025202	89
Scd2 / P13011 / stearoyl-Coenzyme A desaturase 2 / SCD* / O00767* / stearoyl-CoA desaturase*	ENSMUSG00000025203	87
Scd4 / Q6T707 / Acyl-CoA desaturase 4 / SCD* / O00767* / stearoyl-CoA desaturase*	ENSMUSG00000050195	79

Protein motifs (from Interpro)

Interpro ID	Name
IPR001522	Fatty acid desaturase type 1, conserved site
IPR005804	Fatty acid desaturase domain
IPR015876	Acyl-CoA desaturase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006631	fatty acid metabolic process	IEA
biological_process	GO:0006633	fatty acid biosynthetic process	IMP
biological_process	GO:0006636	unsaturated fatty acid biosynthetic process	IEA
biological_process	GO:0006641	triglyceride metabolic process	IMP
biological_process	GO:0008610	lipid biosynthetic process	IEA
biological_process	GO:0010873	positive regulation of cholesterol esterification	TAS
biological_process	GO:0033561	regulation of water loss via skin	IMP
biological_process	GO:0034434	sterol esterification	IMP
biological_process	GO:0034435	cholesterol esterification	IMP
biological_process	GO:0044130	negative regulation of growth of symbiont in host	IMP
biological_process	GO:0048733	sebaceous gland development	IMP
biological_process	GO:0050830	defense response to Gram-positive bacterium	IMP
biological_process	GO:0050872	white fat cell differentiation	IDA
biological_process	GO:0050873	brown fat cell differentiation	IDA
biological_process	GO:0055114	oxidation-reduction process	IEA
biological_process	GO:0070542	response to fatty acid	IEA
biological_process	GO:1903699	tarsal gland development	IMP
biological_process	GO:1903966	monounsaturated fatty acid biosynthetic process	IMP
cellular_component	GO:0005730	nucleolus	ISO
cellular_component	GO:0005783	endoplasmic reticulum	ISO
cellular_component	GO:0005789	endoplasmic reticulum membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	ISO
cellular_component	GO:0030176	integral component of endoplasmic reticulum membrane	IDA
cellular_component	GO:0031090	organelle membrane	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0004768	stearoyl-CoA 9-desaturase activity	ISO
molecular_function	GO:0005506	iron ion binding	IEA
molecular_function	GO:0016491	oxidoreductase activity	ISO
molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IEA
molecular_function	GO:0032896	palmitoyl-CoA 9-desaturase activity	IGI
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Fatty acyl-CoA biosynthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000180	abnormal circulating cholesterol level	"anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0000187	abnormal triglyceride level	"anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam,Sirt3^tm1.1Fwa/Sirt3^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas) Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0000381	enlarged hair follicles	"increased size of the epidermal invaginations from which the hair shaft develops" [J:30249]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0000384	distorted hair follicle pattern	"twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas) Allelic Composition: Scd1^flk/Scd1^flk Genetic Background: C57BL/6J-Scd1^flk Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0000417	short hair	"reduced average length of the hairs" [J:64948]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0000427	abnormal hair cycle	"aberrant growth or asynchronous timing of the hair growth " [J:65302]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0000649	sebaceous gland atrophy	"wasting or decreased size of holocrine glands of the dermis that secrete sebum into the hair follicles" [J:65146]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Scd1^flk/Scd1^flk Genetic Background: C57BL/6J-Scd1^flk
MP:0001191	abnormal skin condition	"anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: Scd1^flk/Scd1^flk Genetic Background: C57BL/6J-Scd1^flk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0001195	flaky skin	"shedding scales on the skin " [J:56641]	Show Allelic Composition: Scd1^flk/Scd1^flk Genetic Background: C57BL/6J-Scd1^flk Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0001209	spontaneous skin ulceration	"unpredictable appearance of skin lesions, usually with inflammation" [J:65302]	Show Allelic Composition: Scd1^flk/Scd1^flk Genetic Background: C57BL/6J-Scd1^flk
MP:0001211	wrinkled skin	"irregular folds and/or indentations on the skin" [J:19212]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas) Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0001243	abnormal dermal layer morphology	"malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0001245	thick dermal layer	"increased depth of the dermis" [J:65033]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0001345	meibomian gland atrophy	"wasting of the sebaceous glands embedded in the tarsal plate of each eyelid resulting in reduced size" [J:65146]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001431	abnormal eating behavior	"inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0001433	polyphagia	"eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0001762	polyuria	"increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0001783	decreased white fat amount	"reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam Genetic Background: involves: C57BL/6
MP:0001874	acanthosis	"diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0001927	abnormal oestrous cycle (sensu Rodentia)	"failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0002001	blindness	"loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas) Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas) Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam,Sirt3^tm1.1Fwa/Sirt3^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0002310	resistance to fatty liver development	"less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam Genetic Background: involves: C57BL/6
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scd1^flk/Scd1^flk Genetic Background: C57BL/6J-Scd1^flk
MP:0002500	granulomatous inflammation	"chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0002575	increased circulating ketone body level	"greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam Genetic Background: involves: C57BL/6
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002796	impaired skin barrier function	"impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam Genetic Background: involves: C57BL/6
MP:0002992	abnormal sebaceous lipid secretion	"abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^flk/Scd1^flk Genetic Background: C57BL/6J-Scd1^flk
MP:0003089	reduced skin tensile strength	"reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0003383	abnormal gluconeogenesis	"anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0003427	parakeratosis	"abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0003704	abnormal hair follicle development	"anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0003809	abnormal hair shaft morphology	"irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0003846	matted coat	"coat hairs sticks together to form clumps and does not lie flat" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0003853	dry skin	"skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J Allelic Composition: Scd1^ab-J/Scd1^ab-J Genetic Background: ABJ/LeJ-Scd1^ab-J
MP:0003976	decreased circulating VLDL triglyceride level	"lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0005146	decreased circulating VLDL cholesterol level	"less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0005176	eyelids fail to open	"eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0005266	abnormal metabolism	"anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0005278	abnormal cholesterol homeostasis	"anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005284	increased saturated fatty acid level	"greater than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain contains only single carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005285	decreased unsaturated fatty acid level	"less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005287	narrow eye opening	"less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam Genetic Background: involves: C57BL/6
MP:0005318	decreased triglyceride level	"lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0005334	abnormal fat pad	"malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0005439	decreased glycogen level	"less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J Allelic Composition: Scd1^{Gt(OST102902)Lex}/Scd1^{Gt(OST102902)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0005501	abnormal skin physiology	"atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam Genetic Background: involves: C57BL/6
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam Genetic Background: involves: C57BL/6
MP:0006319	abnormal epididymal fat pad	"any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0008418	abnormal cutaneous elastic fiber morphology	"any structural anomaly of the slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0008438	abnormal cutaneous collagen fibril morphology	"any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0008900	abnormal uterine fat pad morphology	"any structural anomaly of the encapsulated adipose tissue associated with the uterus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0009004	progressive hair loss	"thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0009011	prolonged diestrus	"increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0009293	decreased inguinal fat pad weight		Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0009305	decreased retroperitoneal fat pad weight		Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam Allelic Composition: Scd1^tm1Ntam/Scd1^tm1Ntam Genetic Background: involves: C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0009535	abnormal skin sebaceous gland morphology	"any structural anomaly of the holocrine glands of the dermis that secrete sebum into the hair follicles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0009675	orthokeratosis	"thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0010681	abnormal hair follicle bulb morphology	"any structural anomaly of the thickened portion of the proximal portion of the hair follicle that contains rapidly proliferating matrix cells, melanocytes and outer root sheath cells" [PMID:19211055]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0010684	abnormal hair follicle outer root sheath morphology	"any structural anomaly of the outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [PMID:19211055]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk
MP:0010685	abnormal hair follicle inner root sheath morphology	"any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas) Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0011941	increased fluid intake	"increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0012725	small sebaceous gland	"decreased size of the sebum secreting glands of the hair shaft" [MGI:mnk]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0013193	sebaceous gland hypoplasia	"underdevelopment and decreased size of the sebum secreting glands of the hair shaft, usually due to a decrease in the number of cells" [MGI:anna]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas) Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0013375	abnormal sebocyte morphology	"any structural anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection" [MGI:Anna, PMID:19944183]	Show Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk Genetic Background: Kunming-Scd1^ab-Xyk Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0013382	small perianal sebaceous gland	"decreased size of the modified holocrine gland that is part of the pilosebaceous unit of a hair located in the area around the anus; each of the specialized large hair follicles that surround and form a network around the anus has a pair of large sebaceous glands that empty into the follicle; perianal glands may function as scent glands" [https://www.inkling.com/read/treuting-comparative-anatomy-histology-1st/chapter-23/mouse-perianal-hair-follicle, MGI:Anna]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0013388	small Meibomian gland	"decreased size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate" [MGI:Anna]	Show Allelic Composition: Scd1^ab-2J/Scd1^ab-2J Genetic Background: DBA/1LacJ-Scd1^ab-2J/J
MP:0013787	photophobia	" abnormal aversion or avoidance behavior in response to light; photophobia is symptom of abnormal intolerance to visual perception of light; as a medical symptom, photophobia is not a morbid fear or phobia, but an experience of discomfort or pain to the eyes due to light exposure or by presence of actual physical sensitivity of the eyes" [http://en.wikipedia.org/wiki/Photophobia, MGI:Anna]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)
MP:0030570	abnormal piliary canal morphology	"any structural anomaly of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft" [PMID:19211055, UBERON:0035610]	Show Allelic Composition: Pax3^tm1Buck/Pax3^tm1Buck,Pax7^tm2Pgr/Pax7^tm2Pgr Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025202	Scd3 / Q99PL7 / Acyl-CoA desaturase 3 / SCD* / O00767* / stearoyl-CoA desaturase*	/ complex
ENSMUSG00000025203	Scd2 / P13011 / stearoyl-Coenzyme A desaturase 2 / SCD* / O00767* / stearoyl-CoA desaturase*	/ complex
ENSMUSG00000037071	Scd1 / P13516 / stearoyl-Coenzyme A desaturase 1 / SCD* / O00767* / stearoyl-CoA desaturase*	/ complex
ENSMUSG00000050195	Scd4 / Q6T707 / Acyl-CoA desaturase 4 / SCD* / O00767* / stearoyl-CoA desaturase*	/ complex

1 s.

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