ENSMUSG00000026280


Mus musculus

Features
Gene ID: ENSMUSG00000026280
  
Biological name :Atg4b
  
Synonyms : Atg4b / autophagy related 4B cysteine peptidase
  
Possible biological names infered from orthology : Q9Y4P1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 93751500
Gene end: 93790610
  
Corresponding Affymetrix probe sets: 10348866 (MoGene1.0st)   1424102_at (Mouse Genome 430 2.0 Array)   1424103_at (Mouse Genome 430 2.0 Array)   1440512_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027502
Ensembl peptide - ENSMUSP00000140758
Ensembl peptide - ENSMUSP00000139541
Ensembl peptide - ENSMUSP00000139463
Ensembl peptide - ENSMUSP00000123383
NCBI entrez gene - 66615     See in Manteia.
MGI - MGI:1913865
RefSeq - NM_174874
RefSeq - XM_006529793
RefSeq Peptide - NP_777363
swissprot - D3YZP6
swissprot - A0A087WNR6
swissprot - A0A0R4J065
swissprot - A0A087WRT0
swissprot - A0A087WNY2
Ensembl - ENSMUSG00000026280
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg4bENSDARG00000052104Danio rerio
 ATG4BENSGALG00000006298Gallus gallus
 ATG4BENSG00000168397Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atg4a-ps / autophagy related 4A, pseudogene / ATG4A* / Q8WYN0* / autophagy related 4A cysteine peptidase*ENSMUSG0000008711954
Atg4a / Q8C9S8 / Cysteine protease ATG4A / Q8WYN0* / autophagy related 4A cysteine peptidase*ENSMUSG0000007941854
Atg4d / Q8BGV9 / Cysteine protease ATG4D Cysteine protease ATG4D, mitochondrial / Q86TL0* / autophagy related 4D cysteine peptidase*ENSMUSG0000000282032
Atg4c / Q811C2 / Cysteine protease ATG4C / Q96DT6* / autophagy related 4C cysteine peptidase*ENSMUSG0000002855028


Protein motifs (from Interpro)
Interpro ID Name
 IPR005078  Peptidase C54
 IPR032916  Cysteine protease ATG4B, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0051697 protein delipidation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg4bGt(OST264114)Lex/Atg4bGt(OST264114)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Atg4bGt(OST264114)Lex/Atg4bGt(OST264114)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002894 abnormal otoliths "malformed crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002978 absent otoliths "absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003143 enlarged otoliths "increased average size of the crystalline calciferous particles adhering to the otolithic membrane" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004330 abnormal saccular macula morphology "any structural abnormalities in the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009979 abnormal cerebellum deep nucleus morphology "any structural anomaly of the gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei" [http://www.spiritus-temporis.com/cerebellum/anatomy.html]
Show

Allelic Composition: Atg4bGt(OST264114)Lex/Atg4bGt(OST264114)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Atg4bGt(OST264114)Lex/Atg4bGt(OST264114)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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