ENSMUSG00000028550


Mus musculus

Features
Gene ID: ENSMUSG00000028550
  
Biological name :Atg4c
  
Synonyms : Atg4c / Cysteine protease ATG4C / Q811C2
  
Possible biological names infered from orthology : autophagy related 4C cysteine peptidase / Q96DT6
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 99193934
Gene end: 99259787
  
Corresponding Affymetrix probe sets: 10506134 (MoGene1.0st)   1434014_at (Mouse Genome 430 2.0 Array)   1441440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030279
Ensembl peptide - ENSMUSP00000137035
NCBI entrez gene - 242557     See in Manteia.
MGI - MGI:2651854
RefSeq - XM_006503073
RefSeq - NM_001145967
RefSeq - NM_175029
RefSeq - XM_006503071
RefSeq - XM_006503072
RefSeq Peptide - NP_001139439
RefSeq Peptide - NP_778194
swissprot - Q811C2
Ensembl - ENSMUSG00000028550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg4cENSDARG00000044373Danio rerio
 ATG4CENSGALG00000010985Gallus gallus
 ATG4CENSG00000125703Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atg4d / Q8BGV9 / Cysteine protease ATG4D Cysteine protease ATG4D, mitochondrial / Q86TL0* / autophagy related 4D cysteine peptidase*ENSMUSG0000000282045
Atg4a-ps / autophagy related 4A, pseudogene / ATG4A* / Q8WYN0* / autophagy related 4A cysteine peptidase*ENSMUSG0000008711926
Atg4a / Q8C9S8 / Cysteine protease ATG4A / Q8WYN0* / autophagy related 4A cysteine peptidase*ENSMUSG0000007941826
Atg4b / autophagy related 4B cysteine peptidase / Q9Y4P1*ENSMUSG0000002628024


Protein motifs (from Interpro)
Interpro ID Name
 IPR005078  Peptidase C54
 IPR032915  Cysteine protease ATG4C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly ISO
 biological_processGO:0000422 autophagy of mitochondrion IBA
 biological_processGO:0006501 C-terminal protein lipidation IBA
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006612 protein targeting to membrane IBA
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0044804 autophagy of nucleus IBA
 biological_processGO:0051697 protein delipidation IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008234 cysteine-type peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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