ENSMUSG00000026414


Mus musculus

Features
Gene ID: ENSMUSG00000026414
  
Biological name :Tnnt2
  
Synonyms : P50752 / Tnnt2 / Troponin T, cardiac muscle
  
Possible biological names infered from orthology : P45379 / troponin T2, cardiac type
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 135836354
Gene end: 135852260
  
Corresponding Affymetrix probe sets: 10350173 (MoGene1.0st)   1418726_a_at (Mouse Genome 430 2.0 Array)   1424967_x_at (Mouse Genome 430 2.0 Array)   1440424_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140807
Ensembl peptide - ENSMUSP00000140282
Ensembl peptide - ENSMUSP00000140941
Ensembl peptide - ENSMUSP00000027671
Ensembl peptide - ENSMUSP00000107715
Ensembl peptide - ENSMUSP00000107716
Ensembl peptide - ENSMUSP00000107717
Ensembl peptide - ENSMUSP00000136265
Ensembl peptide - ENSMUSP00000137093
Ensembl peptide - ENSMUSP00000137579
Ensembl peptide - ENSMUSP00000139669
Ensembl peptide - ENSMUSP00000139919
NCBI entrez gene - 21956     See in Manteia.
MGI - MGI:104597
RefSeq - XM_006529395
RefSeq - NM_001130174
RefSeq - NM_001130175
RefSeq - NM_001130176
RefSeq - NM_001130177
RefSeq - NM_001130178
RefSeq - NM_001130179
RefSeq - NM_001130180
RefSeq - NM_001130181
RefSeq - NM_011619
RefSeq - XM_006529383
RefSeq - XM_006529385
RefSeq - XM_006529388
RefSeq - XM_006529390
RefSeq - XM_006529391
RefSeq - XM_006529392
RefSeq - XM_006529393
RefSeq - XM_006529394
RefSeq Peptide - NP_001123649
RefSeq Peptide - NP_001123650
RefSeq Peptide - NP_001123651
RefSeq Peptide - NP_001123652
RefSeq Peptide - NP_001123653
RefSeq Peptide - NP_035749
RefSeq Peptide - NP_001123646
RefSeq Peptide - NP_001123647
RefSeq Peptide - NP_001123648
swissprot - K3W4R6
swissprot - K3W4R7
swissprot - A0A087WRX3
swissprot - P50752
swissprot - Q54AB6
swissprot - Q6P3Z7
swissprot - A0A087WQP1
swissprot - J3QQ13
Ensembl - ENSMUSG00000026414
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNNT2ENSGALG00000000302Gallus gallus
 TNNT2ENSG00000118194Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnnt1 / O88346 / troponin T1, skeletal, slow / P13805* / troponin T1, slow skeletal type*ENSMUSG0000006417950
Tnnt3 / troponin T3, skeletal, fast / P45378* / troponin T3, fast skeletal type*ENSMUSG0000006172349


Protein motifs (from Interpro)
Interpro ID Name
 IPR001978  Troponin
 IPR027707  Troponin T


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IDA
 biological_processGO:0006937 regulation of muscle contraction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008016 regulation of heart contraction ISO
 biological_processGO:0030049 muscle filament sliding ISS
 biological_processGO:0032780 negative regulation of ATPase activity ISS
 biological_processGO:0032781 positive regulation of ATPase activity ISS
 biological_processGO:0032972 regulation of muscle filament sliding speed IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051592 response to calcium ion ISS
 biological_processGO:0051764 actin crosslink formation IEA
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis IMP
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis ISO
 biological_processGO:0060048 cardiac muscle contraction ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005861 troponin complex IEA
 cellular_componentGO:0005865 striated muscle thin filament ISS
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0030017 sarcomere IDA
 cellular_componentGO:0097512 cardiac myofibril ISO
 cellular_componentGO:1990584 cardiac Troponin complex ISO
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0005200 structural constituent of cytoskeleton IDA
 molecular_functionGO:0005523 tropomyosin binding ISS
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0030172 troponin C binding ISS
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0031013 troponin I binding ISS


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
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Allelic Composition: MitfMi-wh/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi-wh/Mitfmi-sp/J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: MitfMi-wh/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi-wh/Mitfmi-sp/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MitfMi-wh/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi-wh/Mitfmi-sp/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnnt2tm1Mmto/Tnnt2tm1Mmto
Genetic Background: involves: 129S/SvEv

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Plntm1Egk/Plntm1Egk,Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Plntm1Egk/Plntm1Egk,Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: MitfMi-wh/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi-wh/Mitfmi-sp/J

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-wh/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi-wh/Mitfmi-sp/J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfMi-wh/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi-wh/Mitfmi-sp/J

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Tnnt2tm1Mmto/Tnnt2tm1Mmto
Genetic Background: involves: 129S/SvEv

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Plntm1Egk/Plntm1Egk,Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0010553 prolonged HV interval "increase in the length of time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0,Tnnt2tm1Feah/Tnnt2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

Allelic Composition: Tnnt2tm1Mmto/Tnnt2tm1Mmto
Genetic Background: involves: 129S/SvEv

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Bard1tm2Thl/Bard1tm2Thl,Brca1tm1Thl/Brca1tm1Thl,Waptm1(cre)Arge/0
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035458 Tnni3 / P48787 / troponin I, cardiac 3 / P19429* / troponin I3, cardiac type*  / complex
 ENSMUSG00000031097 Tnni2 / P13412 / Troponin I, fast skeletal muscle / P48788* / troponin I2, fast skeletal type*  / complex
 ENSMUSG00000091898 Tnnc1 / P19123 / Troponin C, slow skeletal and cardiac muscles / P63316* / troponin C1, slow skeletal and cardiac type*  / complex
 ENSMUSG00000026418 Tnni1 / Q9WUZ5 / Troponin I, slow skeletal muscle / P19237* / troponin I1, slow skeletal type*  / complex
 ENSMUSG00000017300 Tnnc2 / P20801 / Troponin C, skeletal muscle / P02585* / troponin C2, fast skeletal type*  / complex






 

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