ENSMUSG00000035458


Mus musculus

Features
Gene ID: ENSMUSG00000035458
  
Biological name :Tnni3
  
Synonyms : P48787 / Tnni3 / troponin I, cardiac 3
  
Possible biological names infered from orthology : P19429 / troponin I3, cardiac type
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 4518305
Gene end: 4524229
  
Corresponding Affymetrix probe sets: 10559558 (MoGene1.0st)   1422536_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096458
Ensembl peptide - ENSMUSP00000146966
Ensembl peptide - ENSMUSP00000122916
Ensembl peptide - ENSMUSP00000115015
NCBI entrez gene - 21954     See in Manteia.
MGI - MGI:98783
RefSeq - XM_017322110
RefSeq - NM_009406
RefSeq Peptide - NP_033432
swissprot - D3YXP5
swissprot - D3Z160
swissprot - P48787
swissprot - Q497F1
swissprot - A0A140LIV0
Ensembl - ENSMUSG00000035458
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNNI3ENSG00000129991Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnni1 / Q9WUZ5 / Troponin I, slow skeletal muscle / P19237* / troponin I1, slow skeletal type*ENSMUSG0000002641853
Tnni2 / P13412 / Troponin I, fast skeletal muscle / P48788* / troponin I2, fast skeletal type*ENSMUSG0000003109745


Protein motifs (from Interpro)
Interpro ID Name
 IPR001978  Troponin
 IPR021666  Troponin I residues 1-32


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IDA
 biological_processGO:0001980 regulation of systemic arterial blood pressure by ischemic conditions IMP
 biological_processGO:0003009 skeletal muscle contraction IBA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006937 regulation of muscle contraction IDA
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0006941 striated muscle contraction IDA
 biological_processGO:0007507 heart development IDA
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IEA
 biological_processGO:0032780 negative regulation of ATPase activity IEA
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IEA
 biological_processGO:0060047 heart contraction IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005861 troponin complex IEA
 cellular_componentGO:0030016 myofibril IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0043292 contractile fiber IEA
 cellular_componentGO:0097512 cardiac myofibril IEA
 cellular_componentGO:1990584 cardiac Troponin complex IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0019855 calcium channel inhibitor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030172 troponin C binding IEA
 molecular_functionGO:0031014 troponin T binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000026414 Tnnt2 / P50752 / Troponin T, cardiac muscle / P45379* / troponin T2, cardiac type*  / complex
 ENSMUSG00000064179 Tnnt1 / O88346 / troponin T1, skeletal, slow / P13805* / troponin T1, slow skeletal type*  / complex
 ENSMUSG00000017300 Tnnc2 / P20801 / Troponin C, skeletal muscle / P02585* / troponin C2, fast skeletal type*  / complex
 ENSMUSG00000091898 Tnnc1 / P19123 / Troponin C, slow skeletal and cardiac muscles / P63316* / troponin C1, slow skeletal and cardiac type*  / complex






 

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