ENSMUSG00000026775


Mus musculus

Features
Gene ID: ENSMUSG00000026775
  
Biological name :Yme1l1
  
Synonyms : O88967 / Yme1l1 / YME1-like 1 (S. cerevisiae)
  
Possible biological names infered from orthology : Q96TA2 / YME1 like 1 ATPase
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 23156369
Gene end: 23199260
  
Corresponding Affymetrix probe sets: 10469732 (MoGene1.0st)   1423360_at (Mouse Genome 430 2.0 Array)   1423361_at (Mouse Genome 430 2.0 Array)   1437822_at (Mouse Genome 430 2.0 Array)   1450954_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028117
NCBI entrez gene - 27377     See in Manteia.
MGI - MGI:1351651
RefSeq - NM_013771
RefSeq - XM_017318939
RefSeq Peptide - NP_038799
swissprot - O88967
Ensembl - ENSMUSG00000026775
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 yme1l1aENSDARG00000075192Danio rerio
 yme1l1bENSDARG00000104401Danio rerio
 YME1L1ENSGALG00000007492Gallus gallus
 Q96TA2ENSG00000136758Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000642  Peptidase M41
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005936  Peptidase, FtsH
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037219  Peptidase M41-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006515 protein quality control for misfolded or incompletely synthesized proteins IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0034214 protein hexamerization IEA
 biological_processGO:0034982 mitochondrial protein processing IMP
 biological_processGO:0035694 mitochondrial protein catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004176 ATP-dependent peptidase activity IMP
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nptnpitch/Nptnpitch
Genetic Background: involves: C3H * C57BL/6J

 MP:0011631 decreased mitochondria size "reduced size of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

 MP:0030018 increased cardiac cell glucose uptake "increased ability of the cells of the heart to take in glucose" [MGI:anna]
Show

Allelic Composition: Tent5am1Mhda/Tent5a+
Genetic Background: C3HeB/FeJ-Tent5am1Mhda

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033918 Parl / Q5XJY4 / Presenilins-associated rhomboid-like protein, mitochondrial P-beta / Q9H300* / AC131160.1* / presenilin associated rhomboid like*  / complex
 ENSMUSG00000028455 Q99JB2 / Stoml2 / Stomatin-like protein 2, mitochondrial / Q9UJZ1* / stomatin like 2*  / complex






 

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