ENSMUSG00000027423


Mus musculus

Features
Gene ID: ENSMUSG00000027423
  
Biological name :Snx5
  
Synonyms : Q9D8U8 / Snx5 / Sorting nexin-5
  
Possible biological names infered from orthology : Q9Y5X3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G1
Gene start: 144250123
Gene end: 144270906
  
Corresponding Affymetrix probe sets: 10488237 (MoGene1.0st)   1417646_a_at (Mouse Genome 430 2.0 Array)   1417647_at (Mouse Genome 430 2.0 Array)   1417648_s_at (Mouse Genome 430 2.0 Array)   1437074_at (Mouse Genome 430 2.0 Array)   1448791_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028909
Ensembl peptide - ENSMUSP00000105657
NCBI entrez gene - 69178     See in Manteia.
MGI - MGI:1916428
RefSeq - NM_001199188
RefSeq - NM_024225
RefSeq Peptide - NP_001186117
RefSeq Peptide - NP_077187
swissprot - Q9D8U8
Ensembl - ENSMUSG00000027423
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snx5ENSDARG00000020442Danio rerio
 SNX5ENSGALG00000008691Gallus gallus
 SNX5ENSG00000089006Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Snx6 / Q6P8X1 / Sorting nexin-6 Sorting nexin-6, N-terminally processed / Q9UNH7* / sorting nexin 6*ENSMUSG0000000565664
Snx32 / Q80ZJ7 / Sorting nexin-32 / Q86XE0*ENSMUSG0000005618560
Snx2 / Q9CWK8 / sorting nexin 2 / O60749*ENSMUSG0000003448425
Snx1 / sorting nexin 1 / Q13596*ENSMUSG0000003238222


Protein motifs (from Interpro)
Interpro ID Name
 IPR001683  Phox homologous domain
 IPR014637  Sorting nexin-5/6/32
 IPR015404  Sorting nexin Vps5-like, C-terminal
 IPR027267  AH/BAR domain superfamily
 IPR028654  Sorting nexin-5
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IBA
 biological_processGO:0006907 pinocytosis ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016050 vesicle organization IBA
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISO
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IBA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030904 retromer complex ISS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0031313 extrinsic component of endosome membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070685 macropinocytic cup ISO
 cellular_componentGO:0097422 tubular endosome ISO
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0034452 dynactin binding ISO
 molecular_functionGO:0035091 phosphatidylinositol binding IBA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0010816 decreased type I pneumocyte number "reduced number of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0010902 abnormal pulmonary alveolar sac morphology "any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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