ENSMUSG00000032382


Mus musculus

Features
Gene ID: ENSMUSG00000032382
  
Biological name :Snx1
  
Synonyms : Snx1 / sorting nexin 1
  
Possible biological names infered from orthology : Q13596
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 66088133
Gene end: 66126587
  
Corresponding Affymetrix probe sets: 10594590 (MoGene1.0st)   1416260_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120746
Ensembl peptide - ENSMUSP00000034946
NCBI entrez gene - 56440     See in Manteia.
MGI - MGI:1928395
RefSeq - NM_019727
RefSeq Peptide - NP_062701
swissprot - D3YWH1
swissprot - Q6NZD2
Ensembl - ENSMUSG00000032382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snx1aENSDARG00000071031Danio rerio
 SNX1ENSGALG00000002189Gallus gallus
 SNX1ENSG00000028528Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Snx2 / Q9CWK8 / sorting nexin 2 / O60749*ENSMUSG0000003448460
Snx32 / Q80ZJ7 / Sorting nexin-32 / Q86XE0*ENSMUSG0000005618517
Snx5 / Q9D8U8 / Sorting nexin-5 / Q9Y5X3*ENSMUSG0000002742317
Snx6 / Q6P8X1 / Sorting nexin-6 Sorting nexin-6, N-terminally processed / Q9UNH7* / sorting nexin 6*ENSMUSG0000000565616


Protein motifs (from Interpro)
Interpro ID Name
 IPR001683  Phox homologous domain
 IPR005329  Sorting nexin, N-terminal
 IPR015404  Sorting nexin Vps5-like, C-terminal
 IPR027267  AH/BAR domain superfamily
 IPR028660  Sorting nexin-1
 IPR034901  Sorting Nexin 1, PX domain
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0034498 early endosome to Golgi transport IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0072673 lamellipodium morphogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030904 retromer complex IEA
 cellular_componentGO:0030905 retromer, tubulation complex IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:1990459 transferrin receptor binding IEA
 molecular_functionGO:1990460 leptin receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Grik1tm1Sfh/Grik1tm1Sfh,Grik2tm1Sfh/Grik2tm1Sfh
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: Not Specified

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

Allelic Composition: Snx1tm1Mag/Snx1tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Snx1tm1Mag/Snx1tm1Mag,Snx2tm1Mag/Snx2+,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: Not Specified

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: Not Specified

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag,Vps26atm1Cos/Vps26a+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: Not Specified

 MP:0020515 abnormal visceral yolk sac endoderm morphology "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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