ENSG00000089006


Homo sapiens

Features
Gene ID: ENSG00000089006
  
Biological name :SNX5
  
Synonyms : Q9Y5X3 / SNX5 / sorting nexin 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: p11.23
Gene start: 17941597
Gene end: 17968980
  
Corresponding Affymetrix probe sets: 217792_at (Human Genome U133 Plus 2.0 Array)   222417_s_at (Human Genome U133 Plus 2.0 Array)   223666_at (Human Genome U133 Plus 2.0 Array)   229980_s_at (Human Genome U133 Plus 2.0 Array)   229981_at (Human Genome U133 Plus 2.0 Array)   238433_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475606
Ensembl peptide - ENSP00000479021
Ensembl peptide - ENSP00000476097
Ensembl peptide - ENSP00000475983
Ensembl peptide - ENSP00000366988
Ensembl peptide - ENSP00000366998
Ensembl peptide - ENSP00000404448
Ensembl peptide - ENSP00000406731
Ensembl peptide - ENSP00000475510
NCBI entrez gene - 27131     See in Manteia.
OMIM - 605937
RefSeq - NM_001282454
RefSeq - NM_014426
RefSeq - NM_152227
RefSeq Peptide - NP_001269383
RefSeq Peptide - NP_689413
RefSeq Peptide - NP_055241
swissprot - U3KQP5
swissprot - A0A087WUY5
swissprot - Q5QPE4
swissprot - Q5QPE5
swissprot - Q9Y5X3
swissprot - U3KQL0
swissprot - A0A0S2Z5F1
Ensembl - ENSG00000089006
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snx5ENSDARG00000020442Danio rerio
 SNX5ENSGALG00000008691Gallus gallus
 Snx5ENSMUSG00000027423Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SNX6 / Q9UNH7 / sorting nexin 6ENSG0000012951564
SNX32 / Q86XE0 / sorting nexin 32ENSG0000017280361
SNX2 / O60749 / sorting nexin 2ENSG0000020530225
SNX1 / Q13596 / sorting nexin 1ENSG0000002852822


Protein motifs (from Interpro)
Interpro ID Name
 IPR001683  Phox homologous domain
 IPR014637  Sorting nexin-5/6/32
 IPR015404  Sorting nexin Vps5-like, C-terminal
 IPR027267  AH/BAR domain superfamily
 IPR028654  Sorting nexin-5
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006907 pinocytosis IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016050 vesicle organization IBA
 biological_processGO:0016241 regulation of macroautophagy NAS
 biological_processGO:0042147 retrograde transport, endosome to Golgi NAS
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030904 retromer complex IDA
 cellular_componentGO:0030905 retromer, tubulation complex NAS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0031313 extrinsic component of endosome membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070685 macropinocytic cup IDA
 cellular_componentGO:0097422 tubular endosome IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0034452 dynactin binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding ISS
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity NAS


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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