ENSMUSG00000027998


Mus musculus

Features
Gene ID: ENSMUSG00000027998
  
Biological name :Plrg1
  
Synonyms : Pleiotropic regulator 1 / Plrg1 / Q922V4
  
Possible biological names infered from orthology : O43660
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E3
Gene start: 83055522
Gene end: 83072355
  
Corresponding Affymetrix probe sets: 10492757 (MoGene1.0st)   1448282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113614
Ensembl peptide - ENSMUSP00000114968
Ensembl peptide - ENSMUSP00000029628
NCBI entrez gene - 53317     See in Manteia.
MGI - MGI:1858197
RefSeq - NM_016784
RefSeq Peptide - NP_058064
swissprot - Q922V4
swissprot - D3Z4V1
swissprot - F8WI31
Ensembl - ENSMUSG00000027998
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plrg1ENSDARG00000037283Danio rerio
 PLRG1ENSGALG00000009257Gallus gallus
 PLRG1ENSG00000171566Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Strn3 / Q9ERG2 / striatin, calmodulin binding protein 3 / Q13033* / striatin 3*ENSMUSG0000002095422
Strn / O55106 / Striatin / O43815*ENSMUSG0000002407721
Strn4 / P58404 / Striatin-4 / Q9NRL3*ENSMUSG0000003037421


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0034504 protein localization to nucleus IMP
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0000974 Prp19 complex IBA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005662 DNA replication factor A complex IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0071007 U2-type catalytic step 2 spliceosome IEA
 cellular_componentGO:0071011 precatalytic spliceosome IBA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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