ENSMUSG00000028134


Mus musculus

Features
Gene ID: ENSMUSG00000028134
  
Biological name :Ptbp2
  
Synonyms : Polypyrimidine tract-binding protein 2 / Ptbp2 / Q91Z31
  
Possible biological names infered from orthology : Q9UKA9
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G1
Gene start: 119718742
Gene end: 119784466
  
Corresponding Affymetrix probe sets: 10501778 (MoGene1.0st)   1423470_at (Mouse Genome 430 2.0 Array)   1423471_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142711
Ensembl peptide - ENSMUSP00000143719
Ensembl peptide - ENSMUSP00000143510
Ensembl peptide - ENSMUSP00000143325
Ensembl peptide - ENSMUSP00000143281
Ensembl peptide - ENSMUSP00000029780
Ensembl peptide - ENSMUSP00000142664
NCBI entrez gene - 56195     See in Manteia.
MGI - MGI:1860489
RefSeq - XM_006501732
RefSeq - NM_001310711
RefSeq - NM_019550
RefSeq - XM_006501731
RefSeq Peptide - NP_001297640
RefSeq Peptide - NP_062423
swissprot - Q3V328
swissprot - A0A0G2JEB9
swissprot - A0A0G2JE77
swissprot - Q91Z31
swissprot - A0A0G2JFV8
swissprot - A0A0G2JGW0
Ensembl - ENSMUSG00000028134
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptbp2aENSDARG00000101947Danio rerio
 ptbp2bENSDARG00000015901Danio rerio
 PTBP2ENSGALG00000005552Gallus gallus
 PTBP2ENSG00000117569Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptbp1 / polypyrimidine tract binding protein 1 / P26599*ENSMUSG0000000649873
Ptbp3 / Q8BHD7 / Polypyrimidine tract-binding protein 3 / O95758*ENSMUSG0000002838271
Hnrnpl / Q8R081 / Heteroous nuclear ribonucleoprotein L / P14866* / heterogeneous nuclear ribonucleoprotein L*ENSMUSG0000001516526
Q921F4 / Hnrnpll / Heteroous nuclear ribonucleoprotein L-like / Q8WVV9* / heterogeneous nuclear ribonucleoprotein L like*ENSMUSG0000002409525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR006536  HnRNP-L/PTB
 IPR034798  Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2
 IPR034799  PTBP2, RNA recognition motif 3
 IPR034800  PTBP2, RNA recognition motif 4
 IPR035002  PTBP2, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006376 mRNA splice site selection IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0033119 negative regulation of RNA splicing IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005681 spliceosomal complex IDA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0036002 pre-mRNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Ptbp2tm1.2Dblk/Ptbp2tm1.2Dblk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptbp2tm1.2Dblk/Ptbp2tm1.2Dblk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
Show

Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005237 abnormal olfactory tract morphology "structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]
Show

Allelic Composition: Ptbp2tm1.2Dblk/Ptbp2tm1.2Dblk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptbp2tm1.2Dblk/Ptbp2tm1.2Dblk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptbp2tm1.2Dblk/Ptbp2tm1.2Dblk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0009946 abnormal olfactory bulb layer morphology "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009954 abnormal mitral cell morphology "any structural anomaly of the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J

Allelic Composition: Ptbp2tm1.2Dblk/Ptbp2tm1.2Dblk
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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