ENSMUSG00000028309


Mus musculus

Features
Gene ID: ENSMUSG00000028309
  
Biological name :Rnf20
  
Synonyms : Q5DTM8 / ring finger protein 20 / Rnf20
  
Possible biological names infered from orthology : Q5VTR2
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 49632006
Gene end: 49656887
  
Corresponding Affymetrix probe sets: 10504926 (MoGene1.0st)   1419916_at (Mouse Genome 430 2.0 Array)   1444146_at (Mouse Genome 430 2.0 Array)   1449664_s_at (Mouse Genome 430 2.0 Array)   1452361_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120668
Ensembl peptide - ENSMUSP00000128546
Ensembl peptide - ENSMUSP00000121334
Ensembl peptide - ENSMUSP00000029989
Ensembl peptide - ENSMUSP00000118293
NCBI entrez gene - 109331     See in Manteia.
MGI - MGI:1925927
RefSeq - XM_006537553
RefSeq - XM_017319916
RefSeq - XM_011249906
RefSeq - NM_001163263
RefSeq - NM_182999
RefSeq Peptide - NP_001156735
RefSeq Peptide - NP_892044
swissprot - Q5DTM8
swissprot - A2AIR2
swissprot - A2AIR0
swissprot - A2AIR1
Ensembl - ENSMUSG00000028309
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf20ENSDARG00000016664Danio rerio
 RNF20ENSGALG00000015548Gallus gallus
 RNF20ENSG00000155827Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rnf40 / Q3U319 / ring finger protein 40 / O75150*ENSMUSG0000003081658


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013956  E3 ubiquitin ligase Bre1
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0010390 histone monoubiquitination ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031062 positive regulation of histone methylation IMP
 biological_processGO:0033523 histone H2B ubiquitination IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:1900364 negative regulation of mRNA polyadenylation IEA
 biological_processGO:2001168 positive regulation of histone H2B ubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0033503 HULC complex IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030816 Rnf40 / Q3U319 / ring finger protein 40 / O75150*  / complex
 ENSMUSG00000028309 Rnf20 / Q5DTM8 / ring finger protein 20 / Q5VTR2*  / complex






 

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