ENSMUSG00000028793


Mus musculus

Features
Gene ID: ENSMUSG00000028793
  
Biological name :Rnf19b
  
Synonyms : A2A7Q9 / E3 ubiquitin-protein ligase RNF19B / Rnf19b
  
Possible biological names infered from orthology : Q6ZMZ0 / ring finger protein 19B
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 129058271
Gene end: 129085886
  
Corresponding Affymetrix probe sets: 10508392 (MoGene1.0st)   1432478_a_at (Mouse Genome 430 2.0 Array)   1435226_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030584
Ensembl peptide - ENSMUSP00000131373
Ensembl peptide - ENSMUSP00000121004
Ensembl peptide - ENSMUSP00000119611
Ensembl peptide - ENSMUSP00000095484
NCBI entrez gene - 75234     See in Manteia.
MGI - MGI:1922484
RefSeq - NM_029219
RefSeq - XM_006503458
RefSeq Peptide - NP_083495
swissprot - E9Q2L7
swissprot - F6TQN1
swissprot - B2KG08
swissprot - A2A7Q9
swissprot - A2A7Q8
Ensembl - ENSMUSG00000028793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf19bENSDARG00000060926Danio rerio
 RNF19BENSGALG00000039716Gallus gallus
 Q6ZMZ0ENSG00000116514Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P50636 / Rnf19a / E3 ubiquitin-protein ligase RNF19A / Q9NV58* / ring finger protein 19A, RBR E3 ubiquitin protein ligase*ENSMUSG0000002228057
Q8BKD6 / Rnf144b / E3 ubiquitin-protein ligase RNF144B / Q7Z419* / ring finger protein 144B*ENSMUSG0000003806812
Q925F3 / Rnf144a / E3 ubiquitin-protein ligase RNF144A / P50876* / ring finger protein 144A*ENSMUSG0000002064212
Rnf14 / Q9JI90 / ring finger protein 14 / Q9UBS8*ENSMUSG0000006045010


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR002867  IBR domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IMP
 biological_processGO:0072643 interferon-gamma secretion IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0044194 cytolytic granule IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Foxp3tm8Ayr/Y
Genetic Background: B6.129-Foxp3tm8Ayr

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm8Ayr/Y
Genetic Background: B6.129-Foxp3tm8Ayr

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Foxp3tm8Ayr/Y
Genetic Background: B6.129-Foxp3tm8Ayr

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Foxp3tm8Ayr/Y
Genetic Background: B6.129-Foxp3tm8Ayr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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