ENSMUSG00000038068


Mus musculus

Features
Gene ID: ENSMUSG00000038068
  
Biological name :Rnf144b
  
Synonyms : E3 ubiquitin-protein ligase RNF144B / Q8BKD6 / Rnf144b
  
Possible biological names infered from orthology : Q7Z419 / ring finger protein 144B
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 47122656
Gene end: 47247991
  
Corresponding Affymetrix probe sets: 10404965 (MoGene1.0st)   1425282_at (Mouse Genome 430 2.0 Array)   1439153_at (Mouse Genome 430 2.0 Array)   1443252_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071017
Ensembl peptide - ENSMUSP00000105738
NCBI entrez gene - 218215     See in Manteia.
MGI - MGI:2384986
RefSeq - NM_001170643
RefSeq - NM_146042
RefSeq Peptide - NP_001164114
RefSeq Peptide - NP_666154
swissprot - Q8BKD6
Ensembl - ENSMUSG00000038068
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf144bENSDARG00000024940Danio rerio
 RNF144BENSGALG00000012683Gallus gallus
 Q7Z419ENSG00000137393Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q925F3 / Rnf144a / E3 ubiquitin-protein ligase RNF144A / P50876* / ring finger protein 144A*ENSMUSG0000002064253
A2A7Q9 / Rnf19b / E3 ubiquitin-protein ligase RNF19B / Q6ZMZ0* / ring finger protein 19B*ENSMUSG0000002879329
P50636 / Rnf19a / E3 ubiquitin-protein ligase RNF19A / Q9NV58* / ring finger protein 19A, RBR E3 ubiquitin protein ligase*ENSMUSG0000002228029
Rnf14 / Q9JI90 / ring finger protein 14 / Q9UBS8*ENSMUSG0000006045022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR002867  IBR domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 cellular_componentGO:0000151 ubiquitin ligase complex IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0003900 shortened QT interval "decrease in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Rnf10tm1b(KOMP)Wtsi/Rnf10tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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