ENSMUSG00000028962


Mus musculus

Features
Gene ID: ENSMUSG00000028962
  
Biological name :Slc4a2
  
Synonyms : Slc4a2 / solute carrier family 4 (anion exchanger), member 2
  
Possible biological names infered from orthology : P04920 / solute carrier family 4 member 2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 24423837
Gene end: 24440950
  
Corresponding Affymetrix probe sets: 10520187 (MoGene1.0st)   1416637_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078972
Ensembl peptide - ENSMUSP00000121652
Ensembl peptide - ENSMUSP00000118473
Ensembl peptide - ENSMUSP00000117215
Ensembl peptide - ENSMUSP00000110701
Ensembl peptide - ENSMUSP00000110699
NCBI entrez gene - 20535     See in Manteia.
MGI - MGI:109351
RefSeq - XM_006535656
RefSeq - NM_001253892
RefSeq - NM_009207
RefSeq - XM_006535650
RefSeq - XM_006535651
RefSeq - XM_006535653
RefSeq - XM_006535655
RefSeq Peptide - NP_001240821
RefSeq Peptide - NP_033233
swissprot - A0A0R4J1K9
swissprot - D3Z5G3
swissprot - A0A0R4J101
swissprot - D3YUF1
swissprot - A0A0R4J1K4
swissprot - A0A1C7ZN01
Ensembl - ENSMUSG00000028962
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc4a2aENSDARG00000028173Danio rerio
 slc4a2bENSDARG00000052330Danio rerio
 SLC4A2ENSGALG00000034284Gallus gallus
 P04920ENSG00000164889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P16283 / Slc4a3 / solute carrier family 4 (anion exchanger), member 3 / P48751* / solute carrier family 4 member 3*ENSMUSG0000000657657
P04919 / Slc4a1 / solute carrier family 4 (anion exchanger), member 1 / P02730* / solute carrier family 4 member 1 (Diego blood group)*ENSMUSG0000000657442
Q5DTL9 / Slc4a10 / solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 / Q6U841* / solute carrier family 4 member 10*ENSMUSG0000002690432
Slc4a7 / solute carrier family 4, sodium bicarbonate cotransporter, member 7 / Q9Y6M7* / solute carrier family 4 member 7*ENSMUSG0000002173332
O88343 / Slc4a4 / solute carrier family 4 (anion exchanger), member 4 / Q9Y6R1* / solute carrier family 4 member 4*ENSMUSG0000006096132
Q8JZR6 / Slc4a8 / solute carrier family 4 (anion exchanger), member 8 / Q2Y0W8* / solute carrier family 4 member 8*ENSMUSG0000002303231
Slc4a5 / solute carrier family 4 member 5 / Q9BY07*ENSMUSG0000006832328
Slc4a9 / anion exchange protein 4 isoform 5 / Q96Q91* / solute carrier family 4 member 9*ENSMUSG0000002448527
A2AJN7 / Slc4a11 / Sodium bicarbonate transporter-like protein 11 / Q8NBS3* / solute carrier family 4 member 11*ENSMUSG0000007479618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001717  Anion exchange protein
 IPR002978  Anion exchange protein 2
 IPR003020  Bicarbonate transporter, eukaryotic
 IPR011531  Bicarbonate transporter, C-terminal
 IPR013769  Band 3 cytoplasmic domain
 IPR016152  Phosphotransferase/anion transporter
 IPR018241  Anion exchange, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0051453 regulation of intracellular pH IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0005452 inorganic anion exchanger activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
Bicarbonate transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Slc4a2tm1Ges/Slc4a2tm1Ges
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002660 abnormal caput "anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002661 abnormal corpus "anomalous structure of the body of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Slc4a2tm1Ges/Slc4a2tm1Ges
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
Show

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008003 achlorhydria "absence of hydrochloric acid in the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013566 dilated gastric glands "stretched or widened aperture of the luminal space of any of the branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin" [MGI:Anna]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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