ENSMUSG00000060961


Mus musculus

Features
Gene ID: ENSMUSG00000060961
  
Biological name :Slc4a4
  
Synonyms : O88343 / Slc4a4 / solute carrier family 4 (anion exchanger), member 4
  
Possible biological names infered from orthology : Q9Y6R1 / solute carrier family 4 member 4
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 88886818
Gene end: 89239653
  
Corresponding Affymetrix probe sets: 10523021 (MoGene1.0st)   1421225_a_at (Mouse Genome 430 2.0 Array)   1426432_a_at (Mouse Genome 430 2.0 Array)   1434096_at (Mouse Genome 430 2.0 Array)   1450169_at (Mouse Genome 430 2.0 Array)   1452071_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118413
Ensembl peptide - ENSMUSP00000108844
Ensembl peptide - ENSMUSP00000119325
Ensembl peptide - ENSMUSP00000122975
Ensembl peptide - ENSMUSP00000121744
Ensembl peptide - ENSMUSP00000119976
Ensembl peptide - ENSMUSP00000108842
NCBI entrez gene - 54403     See in Manteia.
MGI - MGI:1927555
RefSeq - XM_017320996
RefSeq - NM_001136260
RefSeq - NM_001197147
RefSeq - NM_001359212
RefSeq - NM_018760
RefSeq - XM_006535136
RefSeq - XM_011249542
RefSeq - XM_011249544
RefSeq - XM_017320995
RefSeq Peptide - NP_001346141
RefSeq Peptide - NP_061230
RefSeq Peptide - NP_001184076
RefSeq Peptide - NP_001129732
swissprot - D3Z7G8
swissprot - O88343
swissprot - A7E1Z5
swissprot - E9Q8N8
swissprot - E1AWU4
swissprot - D3Z7I7
Ensembl - ENSMUSG00000060961
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc4a4aENSDARG00000013730Danio rerio
 slc4a4bENSDARG00000044808Danio rerio
 SLC4A4ENSGALG00000031105Gallus gallus
 Q9Y6R1ENSG00000080493Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc4a5 / solute carrier family 4 member 5 / Q9BY07*ENSMUSG0000006832357
Q5DTL9 / Slc4a10 / solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 / Q6U841* / solute carrier family 4 member 10*ENSMUSG0000002690451
Slc4a7 / solute carrier family 4, sodium bicarbonate cotransporter, member 7 / Q9Y6M7* / solute carrier family 4 member 7*ENSMUSG0000002173351
Q8JZR6 / Slc4a8 / solute carrier family 4 (anion exchanger), member 8 / Q2Y0W8* / solute carrier family 4 member 8*ENSMUSG0000002303251
Slc4a9 / anion exchange protein 4 isoform 5 / Q96Q91* / solute carrier family 4 member 9*ENSMUSG0000002448542
P16283 / Slc4a3 / solute carrier family 4 (anion exchanger), member 3 / P48751* / solute carrier family 4 member 3*ENSMUSG0000000657636
Slc4a2 / solute carrier family 4 (anion exchanger), member 2 / P04920* / solute carrier family 4 member 2*ENSMUSG0000002896236
P04919 / Slc4a1 / solute carrier family 4 (anion exchanger), member 1 / P02730* / solute carrier family 4 member 1 (Diego blood group)*ENSMUSG0000000657430
A2AJN7 / Slc4a11 / Sodium bicarbonate transporter-like protein 11 / Q8NBS3* / solute carrier family 4 member 11*ENSMUSG0000007479619


Protein motifs (from Interpro)
Interpro ID Name
 IPR003020  Bicarbonate transporter, eukaryotic
 IPR003024  Sodium bicarbonate cotransporter
 IPR011531  Bicarbonate transporter, C-terminal
 IPR013769  Band 3 cytoplasmic domain
 IPR016152  Phosphotransferase/anion transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport ISO
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0006885 regulation of pH TAS
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0015701 bicarbonate transport ISS
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 molecular_functionGO:0005452 inorganic anion exchanger activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0008510 sodium:bicarbonate symporter activity ISO
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Bicarbonate transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000126 brittle teeth "fragile and likely to break teeth" [J:61509]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001765 abnormal ion homeostasis "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a4tm1Ges/Slc4a4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003030 acidemia "increased concentration of H-ion in the blood or a fall below normal in pH" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc4a4tm1.1Slin/Slc4a4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc4a4tm1.1Slin/Slc4a4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003267 constipation "incomplete, infrequent or difficult evacuation of fecal matter " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009350 decreased urine pH "increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009422 decreased gastrocnemius weight "reduction in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009477 small cecum "reduced size of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009478 coiled cecum "corkscrew or worm-like appearance of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009644 uremia "an excess of urea, creatinine, and other nitrogenous end products of protein and amino acid metabolism in the blood; usually indicative of kidney dysfunction" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
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Allelic Composition: Slc4a4tm1.1Slin/Slc4a4tm1.1Slin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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