ENSMUSG00000074796


Mus musculus

Features
Gene ID: ENSMUSG00000074796
  
Biological name :Slc4a11
  
Synonyms : A2AJN7 / Slc4a11 / Sodium bicarbonate transporter-like protein 11
  
Possible biological names infered from orthology : Q8NBS3 / solute carrier family 4 member 11
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 130684113
Gene end: 130697519
  
Corresponding Affymetrix probe sets: 10487722 (MoGene1.0st)   1434867_at (Mouse Genome 430 2.0 Array)   1457989_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096963
Ensembl peptide - ENSMUSP00000117976
NCBI entrez gene - 269356     See in Manteia.
MGI - MGI:2138987
RefSeq - NM_001081162
RefSeq - XM_006499604
RefSeq - XM_006499607
RefSeq Peptide - NP_001074631
swissprot - A2AJN8
swissprot - A2AJN7
Ensembl - ENSMUSG00000074796
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc4a11ENSDARG00000075532Danio rerio
 SLC4A11ENSGALG00000016017Gallus gallus
 Q8NBS3ENSG00000088836Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc4a2 / solute carrier family 4 (anion exchanger), member 2 / P04920* / solute carrier family 4 member 2*ENSMUSG0000002896225
P16283 / Slc4a3 / solute carrier family 4 (anion exchanger), member 3 / P48751* / solute carrier family 4 member 3*ENSMUSG0000000657625
Q5DTL9 / Slc4a10 / solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 / Q6U841* / solute carrier family 4 member 10*ENSMUSG0000002690425
Slc4a5 / solute carrier family 4 member 5 / Q9BY07*ENSMUSG0000006832324
Q8JZR6 / Slc4a8 / solute carrier family 4 (anion exchanger), member 8 / Q2Y0W8* / solute carrier family 4 member 8*ENSMUSG0000002303224
O88343 / Slc4a4 / solute carrier family 4 (anion exchanger), member 4 / Q9Y6R1* / solute carrier family 4 member 4*ENSMUSG0000006096124
Slc4a7 / solute carrier family 4, sodium bicarbonate cotransporter, member 7 / Q9Y6M7* / solute carrier family 4 member 7*ENSMUSG0000002173324
P04919 / Slc4a1 / solute carrier family 4 (anion exchanger), member 1 / P02730* / solute carrier family 4 member 1 (Diego blood group)*ENSMUSG0000000657423
Slc4a9 / anion exchange protein 4 isoform 5 / Q96Q91* / solute carrier family 4 member 9*ENSMUSG0000002448523


Protein motifs (from Interpro)
Interpro ID Name
 IPR003020  Bicarbonate transporter, eukaryotic
 IPR011531  Bicarbonate transporter, C-terminal
 IPR016152  Phosphotransferase/anion transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0015701 bicarbonate transport IEA
 biological_processGO:0030003 cellular cation homeostasis IEA
 biological_processGO:0035445 borate transmembrane transport IBA
 biological_processGO:0035725 sodium ion transmembrane transport IBA
 biological_processGO:0042044 fluid transport IMP
 biological_processGO:0046713 borate transport IEA
 biological_processGO:0050801 ion homeostasis IMP
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005452 inorganic anion exchanger activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IBA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IEA
 molecular_functionGO:0015252 proton channel activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IEA
 molecular_functionGO:0046715 active borate transmembrane transporter activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: C1galt1tm1.2Staka/C1galt1tm1.2Staka
Genetic Background: involves: C57BL/6J * DBA/2

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: C1galt1tm1.2Staka/C1galt1tm1.2Staka
Genetic Background: involves: C57BL/6J * DBA/2

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
Show

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0003878 abnormal ear physiology "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
Show

Allelic Composition: Ghrtm1.1Jero/Ghr+
Genetic Background: B6.129X1-Ghrtm1.1Jero

 MP:0004284 abnormal Descemet membrane "any structural abnormality in the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea, considered to be a highly developed basement membrane" [MESH:A09.371.060.217.271, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0004292 abnormal spiral ligament fibrocyte morphology "any structural abnormality in the four types of fibrocytes (types I, II , III and IV) that constitute the spiral ligament" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004411 decreased endocochlear potential "reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004427 abnormal vestibular labyrinth "any structural abnormality in the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ghrtm1.1Jero/Ghr+
Genetic Background: B6.129X1-Ghrtm1.1Jero

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ghrtm1.1Jero/Ghr+
Genetic Background: B6.129X1-Ghrtm1.1Jero

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004814 reduced linear vestibular evoked potential "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ghrtm1.1Jero/Ghr+
Genetic Background: B6.129X1-Ghrtm1.1Jero

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0005301 abnormal corneal endothelium morphology "anomalous structure of the single layer of large flattened cells that cover the surface of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0005544 corneal deposits "accumulation of minerals, proteins, or other anomalous substances on the cornea" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ghrtm1.1Jero/Ghr+
Genetic Background: B6.129X1-Ghrtm1.1Jero

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0009742 increased corneal stroma thickness "increased width of the lamellated connective tissue layer of the cornea" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010062 decreased creatine concentration "reduction in the amount per unit of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0011435 increased urine magnesium level "higher than normal amount of magnesium in the urine" [MGI:anna]
Show

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011436 decreased urine magnesium level "lower than normal amount of magnesium in the urine" [MGI:anna]
Show

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Slc4a11tm1Boet/Slc4a11tm1Boet
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011962 increased cornea thickness "increased width of the cornea in the center plane" [MGI:csmith]
Show

Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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